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    Klrb1c killer cell lectin like receptor B1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klrb1cprovided by RGD
    Official Full Name
    killer cell lectin like receptor B1Cprovided by RGD
    Primary source
    RGD:1583336
    See related
    EnsemblRapid:ENSRNOG00000007811 AllianceGenome:RGD:1583336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Klrb1f; NKR-P1F
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Predicted to be active in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 62.2), Lung (RPKM 23.9) and 6 other tissues See more
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    Genomic context

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    See Klrb1c in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (164068249..164080724)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162380773..162394688)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (162528614..162553421)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member G like 1 Neighboring gene chromobox 3 like 3 Neighboring gene uncharacterized LOC120102406 Neighboring gene uncharacterized LOC134486848 Neighboring gene killer cell lectin like receptor B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NKR-P1dim/TCR alpha beta + T cells and natural killer cells share expression of NKR-P1A and NKR-P1D. Appasamy PM, et al. Nat Immun, 1996-1997. PMID 9390275
    2. Functional characterization of a conserved pair of NKR-P1 receptors expressed by NK cells and T lymphocytes in liver and gut. Kveberg L, et al. Eur J Immunol, 2015 Feb. PMID 25382546
    3. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. Ryan JC, et al. J Immunol, 1992 Sep 1. PMID 1506685
    4. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Spreu J, et al. Proc Natl Acad Sci U S A, 2010 Mar 16. PMID 20194751, Free PMC Article
    5. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. Kung SK, et al. J Immunol, 1999 May 15. PMID 10229823

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NKR-P1F and NKR-P1G receptors expressed by NK cells and T lymphocytes in liver and gut have been functionally characterized.
      Title: Functional characterization of a conserved pair of NKR-P1 receptors expressed by NK cells and T lymphocytes in liver and gut.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily B member 1F
    Names
    NKR-P1B protein
    killer cell lectin-like receptor subfamily B member 1B
    killer cell lectin-like receptor subfamily B member 1C
    natural killer cell surface protein NKR-P1F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085403.2 → NP_001078872.1  killer cell lectin-like receptor subfamily B member 1F

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q63378
      UniProtKB/TrEMBL
      A6IM28
      Related
      ENSRNOP00000107942.1, ENSRNOT00000153277.1
      Conserved Domains (1) summary
      cd03593
      Location:94 → 212
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      164068249..164080724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63378.1 GenPept UniProtKB/Swiss-Prot:Q63378

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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