Rnd2 Rho family GTPase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnd2provided by RGD
Official Full Name: Rho family GTPase 2provided by RGD
Primary source: RGD:1306172
See related: EnsemblRapid:ENSRNOG00000020698 AllianceGenome:RGD:1306172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Arhn; RhoN; Rohn
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to act upstream of or within positive regulation of collateral sprouting. Located in early endosome. Orthologous to human RND2 (Rho family GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 137.6), Testes (RPKM 53.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86899395..86902992)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86399151..86402750)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89376530..89380101)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling
Title: Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.
The RND2 mRNA levels increased significantly was expressed in nonpregnant rat myometrium.
Title: Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133579 (e-PCR)
- UniSTS:216862

NoName (e-PCR)
- UniSTS:488228

NoName (e-PCR)
- UniSTS:490549

MARC_7249-7250:996687691:1 (e-PCR)
- UniSTS:269749

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of collateral sprouting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoN

Names: aplysia ras-related homolog N (RhoN); ras homolog gene family, member N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.