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    Brd3 bromodomain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brd3provided by RGD
    Official Full Name
    bromodomain containing 3provided by RGD
    Primary source
    RGD:1308925
    See related
    EnsemblRapid:ENSRNOG00000007681 AllianceGenome:RGD:1308925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including lncRNA binding activity; lysine-acetylated histone binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including endodermal cell differentiation; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 105.2), Lung (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Brd3 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (31173332..31227749, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10773163..10829675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5995204..6054467, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene vav guanine nucleotide exchange factor 2 Neighboring gene BRD3 opposite strand Neighboring gene microRNA 7578 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene transfer RNA alanine (anticodon AGC) 47 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene WD repeat domain 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. LeRoy G, et al. Mol Cell, 2008 Apr 11. PMID 18406326, Free PMC Article
    2. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Li Y, et al. Mol Cell, 2016 Apr 21. PMID 27105114, Free PMC Article
    3. Histone recognition and large-scale structural analysis of the human bromodomain family. Filippakopoulos P, et al. Cell, 2012 Mar 30. PMID 22464331, Free PMC Article
    4. The bromodomain: from epigenome reader to druggable target. Sanchez R, et al. Biochim Biophys Acta, 2014 Aug. PMID 24686119, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108575.2 → NP_001102045.1  bromodomain-containing protein 3 isoform b

      See identical proteins and their annotated locations for NP_001102045.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JTL2, D3ZWU1
      Related
      ENSRNOP00000059977.2, ENSRNOT00000065867.5
      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:571 → 635
      BET; Bromodomain extra-terminal - transcription regulation

    2. NM_001434270.1 → NP_001421199.1  bromodomain-containing protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5C4, B5DF71

    3. NM_001434271.1 → NP_001421200.1  bromodomain-containing protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5C4, B5DF71

    4. NM_001434272.1 → NP_001421201.1  bromodomain-containing protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5C4, B5DF71

    5. NM_001434273.1 → NP_001421202.1  bromodomain-containing protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JTL2, D3ZWU1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      31173332..31227749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284059.1 → XP_063140129.1  bromodomain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A6JTL2, D3ZWU1

    2. XM_006233826.5 → XP_006233888.1  bromodomain-containing protein 3 isoform X1

      Related
      ENSRNOP00000073373.1, ENSRNOT00000084491.3
      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:588 → 652
      BET; Bromodomain extra-terminal - transcription regulation

    3. XM_006233830.4 → XP_006233892.1  bromodomain-containing protein 3 isoform X2

      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:571 → 635
      BET; Bromodomain extra-terminal - transcription regulation

    4. XM_006233825.4 → XP_006233887.1  bromodomain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:588 → 652
      BET; Bromodomain extra-terminal - transcription regulation

    5. XM_063284060.1 → XP_063140130.1  bromodomain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A6JTL2, D3ZWU1

    6. XM_017591876.3 → XP_017447365.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5C4, B5DF71
      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:588 → 652
      BET; Bromodomain extra-terminal - transcription regulation

    7. XM_039105364.2 → XP_038961292.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5C4, B5DF71
      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:588 → 652
      BET; Bromodomain extra-terminal - transcription regulation

    8. XM_063284062.1 → XP_063140132.1  bromodomain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A6JTL2, D3ZWU1

    9. XM_017591877.3 → XP_017447366.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5C4, B5DF71
      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:588 → 652
      BET; Bromodomain extra-terminal - transcription regulation

    10. XM_063284058.1 → XP_063140128.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5C4, B5DF71

    11. XM_039105362.2 → XP_038961290.1  bromodomain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      cd05497
      Location:34 → 140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311 → 412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:588 → 652
      BET; Bromodomain extra-terminal - transcription regulation

    12. XM_063284061.1 → XP_063140131.1  bromodomain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A6JTL2, D3ZWU1
    Nucleotide Protein Strain
    Heading Accession and Version

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