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    Cpt1a carnitine palmitoyltransferase 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25757, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cpt1aprovided by RGD
    Official Full Name
    carnitine palmitoyltransferase 1Aprovided by RGD
    Primary source
    RGD:2396
    See related
    EnsemblRapid:ENSRNOG00000014254 AllianceGenome:RGD:2396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CPT-Ia
    Summary
    Enables carnitine O-palmitoyltransferase activity and identical protein binding activity. Involved in several processes, including fatty acid metabolic process; liver regeneration; and response to tetrachloromethane. Located in mitochondrial outer membrane. Biomarker of alcoholic hepatitis; end stage renal disease; metabolic dysfunction-associated steatohepatitis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 466.6), Liver (RPKM 466.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cpt1a in Genome Data Viewer
    Location:
    1q42
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (209993881..210056329)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (200564634..200627059)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218568157..218629679)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene uncharacterized LOC134483953 Neighboring gene testis expressed metallothionein like protein Neighboring gene galanin and GMAP prepropeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 34
    Process Evidence Code Pubs
    involved_in aflatoxin metabolic process PubMed 
    involved_in carnitine metabolic process  
    involved_in carnitine metabolic process PubMed 
    involved_in carnitine metabolic process  
    involved_in carnitine metabolic process PubMed 
    involved_in cellular response to fatty acid PubMed 
    involved_in eating behavior PubMed 
    involved_in epithelial cell differentiation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation PubMed 
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process PubMed 
    involved_in fatty acid metabolic process PubMed 
    involved_in glucose metabolic process PubMed 
    involved_in liver regeneration PubMed 
    involved_in long-chain fatty acid metabolic process PubMed 
    involved_in long-chain fatty acid metabolic process PubMed 
    involved_in long-chain fatty acid metabolic process  
    involved_in long-chain fatty acid metabolic process PubMed 
    involved_in positive regulation of fatty acid beta-oxidation PubMed 
    involved_in positive regulation of innate immune response  
    involved_in regulation of fatty acid beta-oxidation PubMed 
    involved_in regulation of fatty acid oxidation PubMed 
    involved_in regulation of insulin secretion PubMed 
    involved_in regulation of lipid storage PubMed 
    involved_in response to alkaloid PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to tetrachloromethane PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in triglyceride metabolic process PubMed 
    Items 1 - 25 of 34
    Component Evidence Code Pubs
    NOT located_in endoplasmic reticulum membrane PubMed 
    located_in membrane  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrial outer membrane  
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    carnitine O-palmitoyltransferase 1, liver isoform
    Names
    CPT I
    CPT1-L
    CPTI-L
    carnitine palmitoyltransferase 1, liver
    carnitine palmitoyltransferase 1a, liver
    succinyltransferase CPT1A
    NP_113747.2
    XP_017444326.1
    XP_038958249.1
    XP_063138421.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031559.2NP_113747.2  carnitine O-palmitoyltransferase 1, liver isoform

      See identical proteins and their annotated locations for NP_113747.2

      Status: VALIDATED

      Source sequence(s)
      AA875270, BC072522
      UniProtKB/Swiss-Prot
      P32198, P97780, Q6IMZ4
      UniProtKB/TrEMBL
      A0A8I5ZQ86, A6HYK3
      Conserved Domains (2) summary
      pfam00755
      Location:171761
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:147
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      209993881..210056329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102321.2XP_038958249.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

      UniProtKB/Swiss-Prot
      P32198, P97780, Q6IMZ4
      UniProtKB/TrEMBL
      A0A8I5ZQ86, A6HYK3
      Related
      ENSRNOP00000019652.1, ENSRNOT00000019652.5
      Conserved Domains (2) summary
      pfam00755
      Location:171761
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:147
      CPT_N; Carnitine O-palmitoyltransferase N-terminus
    2. XM_063282351.1XP_063138421.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

      UniProtKB/Swiss-Prot
      P32198, P97780, Q6IMZ4
      UniProtKB/TrEMBL
      A0A8I5ZQ86, A6HYK3
    3. XM_017588837.2XP_017444326.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

      UniProtKB/Swiss-Prot
      P32198, P97780, Q6IMZ4
      UniProtKB/TrEMBL
      A0A8I5ZQ86, A6HYK3
      Conserved Domains (2) summary
      pfam00755
      Location:171761
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:147
      CPT_N; Carnitine O-palmitoyltransferase N-terminus
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