Tmod1 tropomodulin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmod1provided by RGD
Official Full Name: tropomodulin 1provided by RGD
Primary source: RGD:3874
See related: EnsemblRapid:ENSRNOG00000009761 AllianceGenome:RGD:3874
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmod; E-Tmod
Summary: Enables tropomyosin binding activity. Predicted to be involved in actin cytoskeleton organization; lens fiber cell development; and muscle contraction. Predicted to act upstream of or within adult locomotory behavior. Predicted to be located in cytoskeleton; membrane; and sarcomere. Predicted to be part of COP9 signalosome. Predicted to be active in striated muscle thin filament. Orthologous to human TMOD1 (tropomodulin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 571.8), Muscle (RPKM 537.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (65112062..65189563)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (60316445..60393957)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (61635244..61712052)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tmod1 is required for dendritic spine development and synapse formation.
Title: Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation.
Tmod1 increases dendritic branching distal from the cell body and the number of filopodia/thin spines. Tmod2 increases dendritic branching proximal to the cell body and the number of mature dendritic spines.
Title: Tropomodulin isoforms utilize specific binding functions to modulate dendrite development.
Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes.
Title: Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes.
Lmod contributes to the final organization and maintenance of sarcomere architecture by promoting tropomyosin-dependent actin filament nucleation.
Title: Different localizations and cellular behaviors of leiomodin and tropomodulin in mature cardiomyocyte sarcomeres.
Introduction of E-Tmod cDNA into a tumor cell line reverses TB10 mediated apoptosis and restored actin architectures.
Title: The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture.
Tmod may be involved in the differentiation process in myogenic cells
Title: Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129174 (e-PCR)
- UniSTS:212482

D5Mco30 (e-PCR)
- UniSTS:239364

AU048374 (e-PCR)
- UniSTS:109598

BE101076 (e-PCR)
- UniSTS:243497

BE102142 (e-PCR)
- UniSTS:260693

BM383810 (e-PCR)
- UniSTS:261059

BF391929 (e-PCR)
- UniSTS:249847

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	IDA Inferred from Direct Assay more info	PubMed
enables tropomyosin binding	IEA Inferred from Electronic Annotation more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell development	IEA Inferred from Electronic Annotation more info
involved_in lens fiber cell development	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in pointed-end actin filament capping	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within skeletal muscle myosin thick filament assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in cortical cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
located_in myofibril	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISS Inferred from Sequence or Structural Similarity more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle thin filament	IEA Inferred from Electronic Annotation more info
located_in striated muscle thin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tropomodulin-1

Names: E-Tropomodulin; erythrocyte tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013044.2 → NP_037176.2 tropomodulin-1

See identical proteins and their annotated locations for NP_037176.2

Status: PROVISIONAL

Source sequence(s)

BC072521

UniProtKB/Swiss-Prot

P70567

UniProtKB/TrEMBL

A6IJA9, F7ELP2, Q6IMZ5

Related

ENSRNOP00000013228.3, ENSRNOT00000013228.6

Conserved Domains (2) summary

cd00116
Location:195 → 289

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam03250
Location:3 → 143

Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

65112062..65189563

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287195.1 → XP_063143265.1 tropomodulin-1 isoform X1
XM_039109314.2 → XP_038965242.1 tropomodulin-1 isoform X1

Conserved Domains (2) summary

pfam03250
Location:1 → 41

Tropomodulin

cl39015
Location:93 → 187

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039109315.2 → XP_038965243.1 tropomodulin-1 isoform X1

Conserved Domains (2) summary

pfam03250
Location:1 → 41

Tropomodulin

cl39015
Location:93 → 187

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...