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    Slc6a13 solute carrier family 6 member 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171163, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc6a13provided by RGD
    Official Full Name
    solute carrier family 6 member 13provided by RGD
    Primary source
    RGD:620788
    See related
    EnsemblRapid:ENSRNOG00000012876 AllianceGenome:RGD:620788
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GAT-2
    Summary
    Enables amino acid binding activity; creatine transmembrane transporter activity; and organic acid:sodium symporter activity. Involved in gamma-aminobutyric acid import; neurotransmitter transport; and organic acid transmembrane transport. Located in plasma membrane. Orthologous to human SLC6A13 (solute carrier family 6 member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 388.0), Kidney (RPKM 115.3) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Slc6a13 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156211381..156248491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154539246..154577784)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153874942..153912185)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 18 Neighboring gene uncharacterized LOC102553072 Neighboring gene solute carrier family 6 member 12 Neighboring gene IQ motif and Sec7 domain ArfGEF 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amino acid binding PubMed 
    enables amino acid transmembrane transporter activity  
    enables amino acid:sodium symporter activity  
    enables creatine transmembrane transporter activity PubMed 
    enables gamma-aminobutyric acid transmembrane transporter activity PubMed 
    enables gamma-aminobutyric acid transmembrane transporter activity PubMed 
    enables gamma-aminobutyric acid:sodium:chloride symporter activity  
    enables gamma-aminobutyric acid:sodium:chloride symporter activity PubMed 
    enables gamma-aminobutyric acid:sodium:chloride symporter activity  
    enables gamma-aminobutyric acid:sodium:chloride symporter activity  
    enables metal ion binding  
    enables monocarboxylic acid transmembrane transporter activity  
    enables taurine:sodium symporter activity PubMed 
    enables taurine:sodium symporter activity  
    enables taurine:sodium symporter activity  
    Process Evidence Code Pubs
    involved_in amino acid import across plasma membrane  
    involved_in amino acid transmembrane transport  
    involved_in amino acid transport  
    involved_in creatine transmembrane transport PubMed 
    involved_in gamma-aminobutyric acid import PubMed 
    involved_in gamma-aminobutyric acid import PubMed 
    involved_in gamma-aminobutyric acid transport  
    involved_in monocarboxylic acid transport  
    involved_in neurotransmitter transport PubMed 
    involved_in neurotransmitter transport  
    involved_in nitrogen compound transport PubMed 
    involved_in nitrogen compound transport PubMed 
    acts_upstream_of nitrogen compound transport  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    involved_in taurine transmembrane transport  
    involved_in taurine transmembrane transport PubMed 
    involved_in taurine transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    is_active_in cell projection  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    sodium- and chloride-dependent GABA transporter 2
    Names
    solute carrier family 6 (neurotransmitter transporter), member 13
    solute carrier family 6 (neurotransmitter transporter, GABA), member 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133623.1NP_598307.1  sodium- and chloride-dependent GABA transporter 2

      See identical proteins and their annotated locations for NP_598307.1

      Status: PROVISIONAL

      Source sequence(s)
      M95762
      UniProtKB/Swiss-Prot
      P31646
      UniProtKB/TrEMBL
      A6ILC5, R9PXV0
      Conserved Domains (1) summary
      cl00456
      Location:32575
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      156211381..156248491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237218.5XP_006237280.2  sodium- and chloride-dependent GABA transporter 2 isoform X1

      UniProtKB/TrEMBL
      R9PXV0
      Conserved Domains (1) summary
      cl00456
      Location:32581
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_006237220.5XP_006237282.2  sodium- and chloride-dependent GABA transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      P31646
      UniProtKB/TrEMBL
      A6ILC5, R9PXV0
      Related
      ENSRNOP00000018083.4, ENSRNOT00000018083.5
      Conserved Domains (1) summary
      cl00456
      Location:32575
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_006237219.4XP_006237281.2  sodium- and chloride-dependent GABA transporter 2 isoform X1

      UniProtKB/TrEMBL
      R9PXV0
      Conserved Domains (1) summary
      cl00456
      Location:32581
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_006237221.4XP_006237283.2  sodium- and chloride-dependent GABA transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      P31646
      UniProtKB/TrEMBL
      A6ILC5, R9PXV0
      Conserved Domains (1) summary
      cl00456
      Location:32575
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_006237223.5XP_006237285.2  sodium- and chloride-dependent GABA transporter 2 isoform X5

      UniProtKB/TrEMBL
      R9PXV0
      Conserved Domains (1) summary
      cl00456
      Location:1456
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    6. XM_006237222.5XP_006237284.2  sodium- and chloride-dependent GABA transporter 2 isoform X3

      UniProtKB/TrEMBL
      R9PXV0
      Conserved Domains (1) summary
      cl00456
      Location:25537
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    7. XM_063285457.1XP_063141527.1  sodium- and chloride-dependent GABA transporter 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K0Z3, R9PXV0
      Related
      ENSRNOP00000071638.2, ENSRNOT00000079744.3
    8. XM_039106983.2XP_038962911.1  sodium- and chloride-dependent GABA transporter 2 isoform X6

      Conserved Domains (1) summary
      cl00456
      Location:1296
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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