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    Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79238, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hmgclprovided by RGD
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA lyaseprovided by RGD
    Primary source
    RGD:620554
    See related
    EnsemblRapid:ENSRNOG00000009422 AllianceGenome:RGD:620554
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables carboxylic acid binding activity; fatty-acyl-CoA binding activity; and hydroxymethylglutaryl-CoA lyase activity. Involved in several processes, including ketone body biosynthetic process; liver development; and response to fatty acid. Predicted to be located in peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 532.5), Kidney (RPKM 407.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hmgcl in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153461738..153475552)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148178203..148192072)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154294841..154308582)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cannabinoid receptor 2 Neighboring gene alpha-L-fucosidase 1 Neighboring gene UDP-galactose-4-epimerase Neighboring gene lysophospholipase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylic acid binding PubMed 
    enables fatty-acyl-CoA binding PubMed 
    enables hydroxymethylglutaryl-CoA lyase activity  
    enables hydroxymethylglutaryl-CoA lyase activity PubMed 
    enables hydroxymethylglutaryl-CoA lyase activity  
    enables hydroxymethylglutaryl-CoA lyase activity  
    enables hydroxymethylglutaryl-CoA lyase activity  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables manganese ion binding  
    enables manganese ion binding  
    enables metal ion binding  
    enables metal ion binding  
    enables metal ion binding  
    enables structural molecule activity  
    enables structural molecule activity  
    Process Evidence Code Pubs
    involved_in L-leucine catabolic process  
    involved_in acyl-CoA metabolic process PubMed 
    involved_in ketone body biosynthetic process  
    involved_in ketone body biosynthetic process PubMed 
    involved_in ketone body biosynthetic process  
    involved_in ketone body biosynthetic process  
    involved_in lipid metabolic process  
    involved_in lipid metabolic process  
    involved_in liver development PubMed 
    involved_in mitochondrion organization  
    acts_upstream_of_or_within mitochondrion organization  
    involved_in response to fatty acid PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to starvation PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in peroxisome  
    located_in peroxisome  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    hydroxymethylglutaryl-CoA lyase, mitochondrial
    Names
    3-hydroxy-3-methylglutarate-CoA lyase
    3-hydroxy-3-methylglutaryl-Coenzyme A lyase
    3-hydroxymethyl-3-methylglutaryl-CoA lyase
    3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
    HL
    HMG-CoA lyase
    NP_077362.1
    XP_038966760.1
    XP_063144533.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024386.2NP_077362.1  hydroxymethylglutaryl-CoA lyase, mitochondrial precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P97519
      UniProtKB/TrEMBL
      A0A8L2Q6E3, A6IT78
      Related
      ENSRNOP00000012853.5, ENSRNOT00000012853.8
      Conserved Domains (1) summary
      cl21457
      Location:17325
      TIM; TIM-like beta/alpha barrel domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153461738..153475552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110832.2XP_038966760.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl21457
      Location:17257
      TIM; TIM-like beta/alpha barrel domains
    2. XM_063288463.1XP_063144533.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2

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