Obp3 alpha-2u globulin PGCL4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Obp3provided by RGD
Full Name: alpha-2u globulin PGCL4provided by RGD
Primary source: RGD:708508
See related: EnsemblRapid:ENSRNOG00000065108 AllianceGenome:RGD:708508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables odorant binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 13981.1) See more
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Genomic context

Location:: 5q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (79637234..79640810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (74842316..74845858, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (77313357..77316875, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T. gondii infection enhances hepatic production and urinary excretion of alpha2u-globulins in rats; alpha2u-globulins are sufficient to recapitulate male sexual attractiveness akin to effects of the infection
Title: α2u-globulins mediate manipulation of host attractiveness in Toxoplasma gondii-Rattus novergicus association.
Obp3 binding energetics are modulated by two desolvation processes with quite different thermodynamic signatures
Title: Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3.
Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats.
Title: Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats observed by a proteomic method.
Because rat-OBP3 exhibits typical odorant-binding characteristics, the results not only provide fundamental information on the kinetics of odorant mass transfer induced by the presence of OBPs in the olfactory mucus layer but also support the possibility that vertebrate OBPs may facilitate the accumulation of odorants in the olfactory epithelium
Title: Dynamics of odorant binding to thin aqueous films of rat-OBP3.
The ligand profile for three odorant binding proteins (OBPs) of the rat have been determined using a large number of odorous compounds from different chemical classes.
Title: Odorants of different chemical classes interact with distinct odorant binding protein subtypes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables odorant binding	IDA Inferred from Direct Assay more info	PubMed
enables pheromone binding	IEA Inferred from Electronic Annotation more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-2u globulin PGCL4

Names: alpha2 urinary globulin; major urinary protein-like; odorant-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033958.2 → NP_001029130.2 alpha-2u globulin PGCL4 precursor

See identical proteins and their annotated locations for NP_001029130.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variant 1, 2, and 3 encode the same protein.

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14

Conserved Domains (1) summary

cd19428
Location:26 → 179

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins
NM_001033959.2 → NP_001029131.1 alpha-2u globulin PGCL4 precursor

See identical proteins and their annotated locations for NP_001029131.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variant 1, 2, and 3 encode the same protein.

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14

Conserved Domains (1) summary

cd19428
Location:26 → 179

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins
NM_147215.2 → NP_671748.2 alpha-2u globulin PGCL4 precursor

See identical proteins and their annotated locations for NP_671748.2

Status: VALIDATED

Description

Transcript Variant: The variant (1) represents the longest transcript. Variant 1, 2, and 3 encode the same protein.

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14

Related

ENSRNOP00000048604.6, ENSRNOT00000043056.8

Conserved Domains (1) summary

cd19428
Location:26 → 179

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

79637234..79640810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109326.2 → XP_038965254.1 alpha-2u globulin PGCL4 isoform X2

UniProtKB/TrEMBL

A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14

Conserved Domains (1) summary

cd19428
Location:26 → 179

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins
XM_063287204.1 → XP_063143274.1 alpha-2u globulin PGCL4 isoform X1

UniProtKB/TrEMBL

Q63022, Q63213