Rps6 ribosomal protein S6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rps6provided by RGD
Full Name: ribosomal protein S6provided by RGD
Primary source: RGD:3602
See related: EnsemblRapid:ENSRNOG00000049025 AllianceGenome:RGD:3602
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables mRNA binding activity. A structural constituent of ribosome. Involved in several processes, including cellular response to ethanol; negative regulation of bicellular tight junction assembly; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Is active in GABA-ergic synapse; presynapse; and ribosome. Used to study transient cerebral ischemia. Biomarker of vascular dementia. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 8667.2), Thymus (RPKM 8100.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (106417680..106420540, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (101371716..101374576, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (105197821..105200681, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of this rpS6 was capable of inducing blood-testis barrier remodeling, making the barrier "leaky."
Title: mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model.
a specific deletion of mTOR in Sertoli cells was found to cause an upregulation of p-rpS6-S240/S244 (i.e., an activation of rpS6), but not total rpS6, and was associated with BTB disruption, epithelial damage, loss of cell polarity, and infertility.
Title: F5-Peptide and mTORC1/rpS6 Effectively Enhance BTB Transport Function in the Testis-Lesson From the Adjudin Model.
Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains. results constrain hypotheses about the possible role of rpS6 phosphorylation in regulating postsynaptic protein synthesis during induction of synaptic plasticity.
Title: Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.
TGI-induced sestrin2 expression contributed to RpS6 phosphorylation and neuroprotection against ischemic injury in the hippocampal CA1 subfield.
Title: Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury.
A strong and sustained phosphorylation of ribosomal protein S6 on its serine 240 and 244 residues (p-Ser(2)(2)-S6rp), which was found to be principally expressed in striatal cholinergic interneurons in basal conditions.
Title: Striatal cholinergic interneurons display activity-related phosphorylation of ribosomal protein S6.
rpS6 in the mTORC1 pathway regulates blood-testis barrier restructuring via its effects on the F-actin organization and protein recruitment at the blood-testis barrier
Title: rpS6 Regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment.
Load-dependent maintenance or upregulation of the nucleolar number and/or phosphorylation of S6 and HSP27 plays the important role(s) in the regulation of skeletal muscle mass.
Title: Role(s) of nucleoli and phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass.
functional role of S6 ribosomal protein and upstream positive and negative regulators in the control of smooth muscle cells serum-independent growth
Title: Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131255 (e-PCR)
- UniSTS:214538

RH142222 (e-PCR)
- UniSTS:231472

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell proliferation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation-induced cell death of T cells	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mammalian oogenesis stage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bicellular tight junction assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosomal small subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
is_active_in ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in ribosome	IEA Inferred from Electronic Annotation more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
part_of small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: small ribosomal subunit protein eS6

Names: 40S ribosomal protein S6; 40S ribosomal protein S6-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.