Alad aminolevulinate dehydratase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aladprovided by RGD
Official Full Name: aminolevulinate dehydrataseprovided by RGD
Primary source: RGD:2083
See related: EnsemblRapid:ENSRNOG00000015206 AllianceGenome:RGD:2083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALADH; ALADR
Summary: Enables porphobilinogen synthase activity and proteasome core complex binding activity. Involved in several processes, including cellular response to lead ion; response to herbicide; and response to vitamin B1. Located in extracellular space. Used to study anemia and hemochromatosis. Biomarker of acute kidney failure; hypothyroidism; liver cirrhosis; and status epilepticus. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 448.1), Spleen (RPKM 222.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (80977562..80987901, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (75961993..75972334, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (78368867..78379206, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the inhibition of catalase, delta aminolevulinic acid dehydratase (eth-ALA-D) and isoforms of lactate dehydrogenase (LDH) accompanied by hyperglycemia were prevented by DPDS in all tissues examined.
Title: Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats.
ALAD activity, as well as its gene expression, in the liver of the fatigued animals was decreased as compared with those of the control animals.
Title: Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables porphobilinogen synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables porphobilinogen synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables porphobilinogen synthase activity	IEA Inferred from Electronic Annotation more info
enables porphobilinogen synthase activity	ISO Inferred from Sequence Orthology more info
enables porphobilinogen synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables proteasome core complex binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in heme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme B biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme O biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to aluminum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cobalt ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to platinum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin B1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delta-aminolevulinic acid dehydratase

Names: aminolevulinate, delta-, dehydratase; aminolevulinatedelta-dehydratase; delta - aminolevulinic acid dehydratase; porphobilinogen synthase

NP_037031.1

EC 4.2.1.24

XP_006238296.1

EC 4.2.1.24

XP_006238297.1

EC 4.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429324.1 → NP_001416253.1 delta-aminolevulinic acid dehydratase isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P06214

UniProtKB/TrEMBL

A0A8I6AS85, A6J7V5
NM_001429325.1 → NP_001416254.1 delta-aminolevulinic acid dehydratase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AS85, A0A8L2R0C7
NM_012899.3 → NP_037031.1 delta-aminolevulinic acid dehydratase isoform 1

See identical proteins and their annotated locations for NP_037031.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P06214

UniProtKB/TrEMBL

A0A8I6AS85, A6J7V5

Related

ENSRNOP00000020625.2, ENSRNOT00000020625.8

Conserved Domains (1) summary

cd04824
Location:8 → 327

eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

80977562..80987901 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238235.3 → XP_006238297.1 delta-aminolevulinic acid dehydratase isoform X1

See identical proteins and their annotated locations for XP_006238297.1

UniProtKB/Swiss-Prot

P06214

UniProtKB/TrEMBL

A0A8I6AS85, A6J7V5

Conserved Domains (1) summary

cd04824
Location:8 → 327

eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
XM_006238234.4 → XP_006238296.1 delta-aminolevulinic acid dehydratase isoform X1

Conserved Domains (1) summary

cd04824
Location:8 → 327

eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...