Slc5a2 solute carrier family 5 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a2provided by RGD
Official Full Name: solute carrier family 5 member 2provided by RGD
Primary source: RGD:620217
See related: EnsemblRapid:ENSRNOG00000020039 AllianceGenome:RGD:620217
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sglt2
Summary: Enables D-glucose:sodium symporter activity. Involved in D-glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Located in brush border membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in familial renal glucosuria and renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1071.3) and Lung (RPKM 40.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (192277621..192283742)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182847185..182853309)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199682688..199688809)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold ischemia injury.
Title: Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold ischemia injury.
SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na(+) transport in Dahl SS rats.
Title: SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na(+) transport in Dahl SS rats.
Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves.
Title: Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves.
SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Title: SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2.
Title: Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2.
Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca(2+) homeostasis and promotes cardiac dysfunction.
Title: Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca(2+) homeostasis and promotes cardiac dysfunction.
Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.
Title: Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.
SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models.
Title: SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models.
An SGLT-2 inhibitor was able to exert a glucose-lowering effect in peritoneum exposed to PD solution by inhibiting the activity of SGLT-2.
Title: SGLT-2 inhibitors reduce glucose absorption from peritoneal dialysis solution by suppressing the activity of SGLT-2.
these observations provide a novel mechanism of SGLT2 inhibitors-mediated M2 polarization through a RONS-dependent STAT3-mediated pathway and selective SGLT2 inhibitors are more effective in attenuating myofibroblast infiltration during postinfarction remodeling.
Title: Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts.

Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables D-glucose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables alpha-glucoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables alpha-glucoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucose import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in D-glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in alpha-glucoside transport	IEA Inferred from Electronic Annotation more info
involved_in alpha-glucoside transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal D-glucose absorption	IEA Inferred from Electronic Annotation more info
involved_in renal D-glucose absorption	ISO Inferred from Sequence Orthology more info
involved_in renal D-glucose absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal potassium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/glucose cotransporter 2

Names: Na(+)/glucose cotransporter 2; low affinity Na-dependent glucose transporter (SGLT2); low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose cotransporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022590.2 → NP_072112.2 sodium/glucose cotransporter 2

Status: VALIDATED

Source sequence(s)

AB070850, AB070976, U29881

UniProtKB/Swiss-Prot

P53792

Related

ENSRNOP00000027265.3, ENSRNOT00000027265.5

Conserved Domains (1) summary

cl00456
Location:22 → 670

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain