Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrr3provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit rho3provided by RGD
Primary source: RGD:621564
See related: EnsemblRapid:ENSRNOG00000001679 AllianceGenome:RGD:621564
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA-A receptor activity; GABA-gated chloride ion channel activity; and protein domain specific binding activity. Predicted to be involved in chloride transmembrane transport. Predicted to be part of GABA-A receptor complex. Predicted to be active in GABA-ergic synapse and postsynaptic membrane. Orthologous to human GABRR3 (gamma-aminobutyric acid type A receptor subunit rho3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 5.8), Thymus (RPKM 4.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (54372017..54424466, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (40902812..40955263, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (43046987..43099754, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of GABA(C) receptors in the cerebellum adds a new dimension to the regulation of GABAergic neurotransmission
Title: Expression of GABArho subunits during rat cerebellum development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Rat71 (e-PCR), detects polymorphism
- UniSTS:226424

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit rho-3

Names: GABA receptor rho-3 subunit; GABA(A) receptor subunit rho-3; GABA(C) receptor; GABAAR subunit rho-3; gamma-aminobutyric acid (GABA) A receptor, rho 3; gamma-aminobutyric acid (GABA) receptor, rho 3; gamma-aminobutyric acid type A receptor rho3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138897.2 → NP_620252.1 gamma-aminobutyric acid receptor subunit rho-3 precursor

See identical proteins and their annotated locations for NP_620252.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P50573

UniProtKB/TrEMBL

A6IQJ1

Related

ENSRNOP00000002281.4, ENSRNOT00000002281.6

Conserved Domains (3) summary

TIGR00860
Location:58 → 463

LIC; Cation transporter family protein

cd03558
Location:181 → 195

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:79 → 264

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))