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    Rcc1l RCC1 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360796, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rcc1lprovided by RGD
    Official Full Name
    RCC1 likeprovided by RGD
    Primary source
    RGD:1307558
    See related
    EnsemblRapid:ENSRNOG00000001483 AllianceGenome:RGD:1307558
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wbscr16
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and rRNA binding activity. Predicted to be involved in mitochondrial fusion; positive regulation of mitochondrial translation; and ribosome biogenesis. Predicted to be located in mitochondrial matrix and mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human RCC1L (RCC1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 85.0), Kidney (RPKM 77.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rcc1l in Genome Data Viewer
    Location:
    12q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (28179205..28210462)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22543125..22574042)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25561871..25592337)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene neutrophil cytosolic factor 1 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene uncharacterized LOC134481282 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 2 Neighboring gene uncharacterized LOC102553721 Neighboring gene uncharacterized LOC134481174

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human WBSCR16, an RCC1-like protein in mitochondria. Koyama M, et al. Protein Sci, 2017 Sep. PMID 28608466, Free PMC Article
    2. WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion. Huang G, et al. Cell Rep, 2017 Jul 25. PMID 28746876, Free PMC Article
    3. Identification of additional transcripts in the Williams-Beuren syndrome critical region. Merla G, et al. Hum Genet, 2002 May. PMID 12073013
    4. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Arroyo JD, et al. Cell Metab, 2016 Dec 13. PMID 27667664, Free PMC Article
    5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RCC1-like G exchanging factor-like protein
    Names
    Williams-Beuren syndrome chromosome region 16 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108332.1 → NP_001101802.1  RCC1-like G exchanging factor-like protein

      See identical proteins and their annotated locations for NP_001101802.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J0K7, D4AE90
      Related
      ENSRNOP00000002032.3, ENSRNOT00000002032.7
      Conserved Domains (2) summary
      pfam00415
      Location:298 → 348
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:229 → 258
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      28179205..28210462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249183.5 → XP_006249245.1  RCC1-like G exchanging factor-like protein isoform X1

      Conserved Domains (2) summary
      pfam00415
      Location:298 → 348
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:229 → 258
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    2. XM_039089585.2 → XP_038945513.1  RCC1-like G exchanging factor-like protein isoform X2

      Conserved Domains (2) summary
      COG5184
      Location:56 → 356
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:24 → 83
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    3. XM_039089586.2 → XP_038945514.1  RCC1-like G exchanging factor-like protein isoform X3

      Conserved Domains (2) summary
      COG5184
      Location:35 → 265
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:1 → 48
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RNA

    1. XR_010056405.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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