Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp19a1provided by RGD
Full Name: cytochrome P450, family 19, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:2457
See related: EnsemblRapid:ENSRNOG00000000196 AllianceGenome:RGD:2457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp19; Cyp19a; p450arom; Aromatase
Summary: Enables aromatase activity. Involved in several processes, including gonad development; limbic system development; and steroid metabolic process. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 2.6), Uterus (RPKM 2.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (63449148..63476534, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (54552978..54580375, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (58744849..58772408, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1.
Title: Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1.
TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cellsdagger.
Title: TGF-β1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cells†.
Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell.
Title: Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell.
Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria.
Title: Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria.
Prenatal exposure to bisphenol-A altered miRNA-224 and protein expression of aromatase in ovarian granulosa cells concomitant with elevated serum estradiol levels in F1 adult offspring.
Title: Prenatal exposure to bisphenol-A altered miRNA-224 and protein expression of aromatase in ovarian granulosa cells concomitant with elevated serum estradiol levels in F(1) adult offspring.
data provide evidence of a local increase of aromatase expression by reelin. Regarding reproduction, this crosstalk may contribute to follicular stability and counteract luteinization in ovaries.
Title: Reelin and aromatase cooperate in ovarian follicle development.
We also found a decrease in the number of aromatase-positive, CD68-positive macrophages within the tumor microenvironment, suggesting that metformin targets the immune microenvironment in addition to improving whole-body metabolism
Title: Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer.
In senile rats, expression of aromatase and ERalpha were increased in prostate epithelial cells.
Title: Basal Cells Show Increased Expression of Aromatase and Estrogen Receptor α in Prostate Epithelial Lesions of Male Aging Rats.
These studies suggest an association between adiposity, aromatase estrogenic capacity and atrial arrhythmogenicity.
Title: Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?
Focal ischemia (FI) upregulates brain aromatase in the male rat brain 14 d post surgery; however, the lack of negative correlation between aromatase expression and infarct volume and lack of positive correlation between microgliosis and aromatase do not support a major role for aromatase as a mediator of neuroprotection or a causal relationship between microglial activation and increased aromatase expression in male FI.
Title: Aromatase and neuroinflammation in rat focal brain ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (59)

General gene information

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Markers

RH133046 (e-PCR)
- UniSTS:216329

Cyp19a1 (e-PCR), detects polymorphism
- UniSTS:256606

D8Arb12 (e-PCR), detects polymorphism
- UniSTS:228200

RH128871 (e-PCR)
- UniSTS:212179

D8Wox16 (e-PCR)
- UniSTS:518624

CYP19-3 (e-PCR)
- UniSTS:253945

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aromatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables aromatase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in androgen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in androgen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in biphenyl metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in bone development	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcineurin-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to gonadotropin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrostatic pressure	IEP Inferred from Expression Pattern more info	PubMed
involved_in dibenzo-p-dioxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in female genitalia development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female genitalia development	ISO Inferred from Sequence Orthology more info
involved_in female gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in female gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
involved_in granulocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in luteinization	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammary gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in melatonin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chronic inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of chronic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in phthalate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of estradiol secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of estradiol secretion	ISO Inferred from Sequence Orthology more info
involved_in prostate gland growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in testosterone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in uterus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aromatase

Names: CYPXIX; Cytochrome P450, 19, aromatase; P-450AROM; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450 19A1-like; cytochrome P450 family 19 subfamily a; cytochrome P450, subfamily 19; estrogen synthase; estrogen synthetase

NP_058781.2

EC 1.14.14.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.