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    Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312912, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Prex2provided by RGD
    Official Full Name
    phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2provided by RGD
    Primary source
    RGD:1307865
    See related
    EnsemblRapid:ENSRNOG00000005391 AllianceGenome:RGD:1307865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Depdc2
    Summary
    Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; negative regulation of TOR signaling; and negative regulation of protein kinase activity. Predicted to act upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 555.7), Brain (RPKM 258.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prex2 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (12720683..13036077, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (7937692..8253112, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (7622668..7941715, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene similar to human chromosome 8 open reading frame 34 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134487055 Neighboring gene uncharacterized LOC134487109

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Leveraging methylation to identify the potential causal genes associated with survival in lung adenocarcinoma and lung squamous cell carcinoma. Liu L, et al. Oncol Lett, 2020 Jul. PMID 32537022, Free PMC Article
    2. LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340. Yu J, et al. Hum Cell, 2020 Jan. PMID 31776854
    3. Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues. Liao Z, et al. Sci Rep, 2016 Dec 21. PMID 28000796, Free PMC Article
    4. MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. Liao Z, et al. Oncol Res, 2020 Mar 27. PMID 31711559, Free PMC Article
    5. The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2. Lan X, et al. J Mol Histol, 2014 Dec. PMID 25151370

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
    Names
    DEP domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393795.1 → NP_001380724.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2KA11
      Related
      ENSRNOP00000099324.1, ENSRNOT00000126928.1
      Conserved Domains (6) summary
      cd00992
      Location:669 → 736
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04439
      Location:374 → 454
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:466 → 558
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:210 → 356
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00621
      Location:19 → 204
      RhoGEF; RhoGEF domain
      pfam17820
      Location:607 → 660
      PDZ_6; PDZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      12720683..13036077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107899.2: Suppressed sequence

      Description
      NM_001107899.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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