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    Slc10a7 solute carrier family 10, member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291942, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc10a7provided by RGD
    Official Full Name
    solute carrier family 10, member 7provided by RGD
    Primary source
    RGD:1564388
    See related
    EnsemblRapid:ENSRNOG00000011991 AllianceGenome:RGD:1564388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P7
    Summary
    Predicted to enable bile acid transmembrane transporter activity. Predicted to be involved in bone development; heparin biosynthetic process; and intracellular calcium ion homeostasis. Located in endoplasmic reticulum and plasma membrane. Orthologous to human SLC10A7 (solute carrier family 10 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 54.8), Lung (RPKM 54.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc10a7 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (46087440..46311753, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (29183143..29407470, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (32857984..33081359, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483636 Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene U4 spliceosomal RNA Neighboring gene reeler domain containing 1 Neighboring gene large ribosomal subunit protein eL28-like Neighboring gene Rbmx like 1 Neighboring gene 60S ribosomal protein L21-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SLC10A7 mutations cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects. Dubail J, et al. Nat Commun, 2018 Aug 6. PMID 30082715, Free PMC Article
    2. Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation. Ashikov A, et al. Hum Mol Genet, 2018 Sep 1. PMID 29878199
    3. Homo- and hetero-dimeric architecture of the human liver Na⁺-dependent taurocholate co-transporting protein. Bijsmans IT, et al. Biochem J, 2012 Feb 1. PMID 22029531
    4. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Godoy JR, et al. Eur J Cell Biol, 2007 Aug. PMID 17628207
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular characterization and expression analysis of a novel member of the SLC10 family, SLC10A7, previously known as C4orf13, is reported
      Title: Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sodium/bile acid cotransporter 7
    Names
    Na(+)/bile acid cotransporter 7
    solute carrier family 10 (sodium/bile acid cotransporter family), member 7
    solute carrier family 10 (sodium/bile acid cotransporter family), member 7-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010948.2 → NP_001010948.1  sodium/bile acid cotransporter 7

      See identical proteins and their annotated locations for NP_001010948.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q5PT50
      UniProtKB/TrEMBL
      A0A8L2Q8N4, A6IYJ4
      Related
      ENSRNOP00000015985.8, ENSRNOT00000015985.9
      Conserved Domains (1) summary
      pfam13593
      Location:10 → 320
      SBF_like; SBF-like CPA transporter family (DUF4137)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      46087440..46311753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097586.2 → XP_038953514.1  sodium/bile acid cotransporter 7 isoform X3

      Conserved Domains (1) summary
      cl19217
      Location:10 → 249
      SBF; Sodium Bile acid symporter family

    2. XM_039097585.2 → XP_038953513.1  sodium/bile acid cotransporter 7 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q8N4
      Related
      ENSRNOP00000077134.2, ENSRNOT00000097147.2
      Conserved Domains (1) summary
      pfam13593
      Location:10 → 307
      SBF_like; SBF-like CPA transporter family (DUF4137)

    3. XM_063277890.1 → XP_063133960.1  sodium/bile acid cotransporter 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJM8

    4. XM_063277889.1 → XP_063133959.1  sodium/bile acid cotransporter 7 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q8N4
      Related
      ENSRNOP00000107182.1, ENSRNOT00000147369.1

    5. XM_063277891.1 → XP_063133961.1  sodium/bile acid cotransporter 7 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PT50.1 GenPept UniProtKB/Swiss-Prot:Q5PT50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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