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    Tmco5a transmembrane and coiled-coil domains 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmco5aprovided by RGD
    Official Full Name
    transmembrane and coiled-coil domains 5Aprovided by RGD
    Primary source
    RGD:1565206
    See related
    EnsemblRapid:ENSRNOG00000005100 AllianceGenome:RGD:1565206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmco5; RGD1565206
    Summary
    Predicted to be located in membrane. Orthologous to human TMCO5A (transmembrane and coiled-coil domains 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 184.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmco5a in Genome Data Viewer
    Location:
    3q35
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (124187005..124200308)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (103732936..103746242)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (108544922..108559448)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555456 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134486426 Neighboring gene small nucleolar RNA U13 Neighboring gene enolase 1, pseudogene 25 Neighboring gene sprouty-related, EVH1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A membrane protein, TMCO5A, has a close relationship with manchette microtubules in rat spermatids during spermiogenesis. Kaneko T, et al. Mol Reprod Dev, 2019 Mar. PMID 30632224

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It is likely that TMCO5A, in association with manchette microtubules, is involved in the process of spermiogenesis.
      Title: A membrane protein, TMCO5A, has a close relationship with manchette microtubules in rat spermatids during spermiogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain-containing protein 5A; transmembrane and coiled-coil domains 5A
    Names
    transmembrane and coiled-coil domains 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430776.1 → NP_001417705.1  transmembrane and coiled-coil domains 5A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A3G0

    2. NM_001430777.1 → NP_001417706.1  transmembrane and coiled-coil domains 5A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A3G0

    3. NM_001430779.1 → NP_001417708.1  transmembrane and coiled-coil domains 5A isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A3G0

    4. NM_001430780.1 → NP_001417709.1  transmembrane and coiled-coil domains 5A isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A3G0

    5. NM_001430781.1 → NP_001417710.1  transmembrane and coiled-coil domains 5A isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HP91

    6. NM_001430782.1 → NP_001417711.1  transmembrane and coiled-coil domains 5A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A3G0

    7. NM_001430784.1 → NP_001417713.1  transmembrane and coiled-coil domains 5A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A3G0

    8. NM_001430785.1 → NP_001417714.1  transmembrane and coiled-coil domains 5A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A3G0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      124187005..124200308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285298.1 → XP_063141368.1  transmembrane and coiled-coil domain-containing protein 5A isoform X6

      UniProtKB/TrEMBL
      A0A8I6A3G0

    2. XM_063285301.1 → XP_063141371.1  transmembrane and coiled-coil domain-containing protein 5A isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3G0

    3. XM_063285297.1 → XP_063141367.1  transmembrane and coiled-coil domain-containing protein 5A isoform X5

      UniProtKB/TrEMBL
      A0A8I6A3G0

    4. XM_063285304.1 → XP_063141374.1  transmembrane and coiled-coil domain-containing protein 5A isoform X11

      UniProtKB/TrEMBL
      A6HP91

    5. XM_039106485.2 → XP_038962413.1  transmembrane and coiled-coil domain-containing protein 5A isoform X5

      Conserved Domains (1) summary
      pfam14992
      Location:28 → 302
      TMCO5; TMCO5 family

    6. XM_063285300.1 → XP_063141370.1  transmembrane and coiled-coil domain-containing protein 5A isoform X7

      UniProtKB/TrEMBL
      A0A8I6A3G0
      Related
      ENSRNOP00000006809.7, ENSRNOT00000006809.9

    7. XM_063285299.1 → XP_063141369.1  transmembrane and coiled-coil domain-containing protein 5A isoform X6

      UniProtKB/TrEMBL
      A0A8I6A3G0

    8. XM_063285303.1 → XP_063141373.1  transmembrane and coiled-coil domain-containing protein 5A isoform X10

      UniProtKB/TrEMBL
      A0A8I6A3G0

    9. XM_063285296.1 → XP_063141366.1  transmembrane and coiled-coil domain-containing protein 5A isoform X4

      UniProtKB/TrEMBL
      A0A8I6A3G0

    10. XM_063285294.1 → XP_063141364.1  transmembrane and coiled-coil domain-containing protein 5A isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3G0

    11. XM_063285295.1 → XP_063141365.1  transmembrane and coiled-coil domain-containing protein 5A isoform X3

      UniProtKB/TrEMBL
      A0A8I6A3G0

    12. XM_063285302.1 → XP_063141372.1  transmembrane and coiled-coil domain-containing protein 5A isoform X9

      UniProtKB/TrEMBL
      A0A8I6A3G0

    13. XM_039106479.2 → XP_038962407.1  transmembrane and coiled-coil domain-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3G0
      Related
      ENSRNOP00000085222.2, ENSRNOT00000103870.2
      Conserved Domains (1) summary
      pfam14992
      Location:36 → 310
      TMCO5; TMCO5 family

    14. XM_039106480.2 → XP_038962408.1  transmembrane and coiled-coil domain-containing protein 5A isoform X1

      Conserved Domains (1) summary
      pfam14992
      Location:36 → 310
      TMCO5; TMCO5 family
    Nucleotide Protein Strain
    Heading Accession and Version

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