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    Ccdc57 coiled-coil domain containing 57 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688324, updated on 27-Dec-2024

    Summary

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    Symbol
    Ccdc57provided by RGD
    Full Name
    coiled-coil domain containing 57provided by RGD
    Primary source
    RGD:1590047
    See related
    EnsemblRapid:ENSRNOG00000047531 AllianceGenome:RGD:1590047
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; cilium assembly; and microtubule cytoskeleton organization. Predicted to be located in centrosome. Predicted to be active in centriolar satellite; centriole; and spindle microtubule. Orthologous to human CCDC57 (coiled-coil domain containing 57). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 47.6), Kidney (RPKM 30.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc57 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106591106..106694740, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106092784..106196405, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110046012..110110775, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095225 Neighboring gene fatty acid synthase Neighboring gene dolichyl-phosphate mannosyltransferase subunit 3, regulatory, pseudogene 2 Neighboring gene solute carrier family 16 member 3 Neighboring gene casein kinase 1, delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain containing 57; coiled-coil domain-containing protein 57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106591106..106694740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270205.1 → XP_063126275.1  coiled-coil domain-containing protein 57 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSM9

    2. XM_063270202.1 → XP_063126272.1  coiled-coil domain-containing protein 57 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSM9

    3. XM_063270204.1 → XP_063126274.1  coiled-coil domain-containing protein 57 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSM9

    4. XM_039087556.2 → XP_038943484.1  coiled-coil domain-containing protein 57 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSM9
      Conserved Domains (3) summary
      PHA03307
      Location:911 → 1135
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:28 → 718
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:53 → 394
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_039087567.2 → XP_038943495.1  coiled-coil domain-containing protein 57 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZSM9
      Conserved Domains (3) summary
      PHA03307
      Location:778 → 1002
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:126 → 409
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:195 → 584
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_039087568.2 → XP_038943496.1  coiled-coil domain-containing protein 57 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZSM9
      Conserved Domains (3) summary
      PHA03307
      Location:778 → 1002
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:126 → 409
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:195 → 584
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_039087565.2 → XP_038943493.1  coiled-coil domain-containing protein 57 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZSM9
      Conserved Domains (2) summary
      PHA03307
      Location:816 → 1040
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:28 → 623
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_039087563.2 → XP_038943491.1  coiled-coil domain-containing protein 57 isoform X6

      UniProtKB/TrEMBL
      M0R9E4
      Conserved Domains (2) summary
      PHA03307
      Location:841 → 1065
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:36 → 744
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_039087559.2 → XP_038943487.1  coiled-coil domain-containing protein 57 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSM9
      Conserved Domains (3) summary
      PHA03307
      Location:883 → 1107
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:321 → 690
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:53 → 394
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. XM_063270211.1 → XP_063126281.1  coiled-coil domain-containing protein 57 isoform X10

      UniProtKB/TrEMBL
      M0R9E4

    11. XM_063270209.1 → XP_063126279.1  coiled-coil domain-containing protein 57 isoform X10

      UniProtKB/TrEMBL
      M0R9E4

    12. XM_063270210.1 → XP_063126280.1  coiled-coil domain-containing protein 57 isoform X10

      UniProtKB/TrEMBL
      M0R9E4

    13. XM_063270208.1 → XP_063126278.1  coiled-coil domain-containing protein 57 isoform X10

      UniProtKB/TrEMBL
      M0R9E4

    14. XM_063270206.1 → XP_063126276.1  coiled-coil domain-containing protein 57 isoform X10

      UniProtKB/TrEMBL
      M0R9E4

    15. XM_063270207.1 → XP_063126277.1  coiled-coil domain-containing protein 57 isoform X10

      UniProtKB/TrEMBL
      M0R9E4

    16. XM_039087569.2 → XP_038943497.1  coiled-coil domain-containing protein 57 isoform X11

      UniProtKB/TrEMBL
      M0R9E4
      Conserved Domains (3) summary
      PHA03307
      Location:649 → 873
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:1 → 280
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:66 → 455
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    17. XM_039087566.2 → XP_038943494.1  coiled-coil domain-containing protein 57 isoform X8

      UniProtKB/TrEMBL
      M0R9E4
      Related
      ENSRNOP00000066112.4, ENSRNOT00000071893.4
      Conserved Domains (2) summary
      PHA03307
      Location:813 → 1037
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:28 → 620
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    18. XM_039087571.2 → XP_038943499.1  coiled-coil domain-containing protein 57 isoform X12

      Conserved Domains (2) summary
      PHA03307
      Location:566 → 790
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:3 → 373
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    19. XM_063270203.1 → XP_063126273.1  coiled-coil domain-containing protein 57 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSM9
      Related
      ENSRNOP00000091858.2, ENSRNOT00000098223.2

    20. XM_039087570.1 → XP_038943498.1  coiled-coil domain-containing protein 57 isoform X11

      UniProtKB/TrEMBL
      M0R9E4
      Conserved Domains (3) summary
      PHA03307
      Location:649 → 873
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:1 → 280
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:66 → 455
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    21. XM_039087561.2 → XP_038943489.1  coiled-coil domain-containing protein 57 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZSM9
      Conserved Domains (2) summary
      COG1196
      Location:28 → 718
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:53 → 394
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    22. XM_039087562.2 → XP_038943490.1  coiled-coil domain-containing protein 57 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y209
      Conserved Domains (2) summary
      COG1196
      Location:28 → 718
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:53 → 394
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    23. XM_039087572.2 → XP_038943500.1  coiled-coil domain-containing protein 57 isoform X13

      Conserved Domains (1) summary
      TIGR02168
      Location:53 → 394
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_010055923.1 RNA Sequence

    2. XR_005490602.2 RNA Sequence

    3. XR_005490603.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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