Cerkl CERK like autophagy regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cerklprovided by RGD
Official Full Name: CERK like autophagy regulatorprovided by RGD
Primary source: RGD:1561057
See related: EnsemblRapid:ENSRNOG00000030212 AllianceGenome:RGD:1561057
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561057
Summary: Predicted to enable lipid kinase activity and sphingolipid binding activity. Predicted to be involved in negative regulation of apoptotic process and sphingolipid metabolic process. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be located in several cellular components, including nuclear lumen; photoreceptor inner segment; and photoreceptor outer segment. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 26. Orthologous to human CERKL (CERK like autophagy regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 14.6), Lung (RPKM 11.4) and 8 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (84641121..84747999, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (64238714..64344695, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (66268835..66395615, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
NOT enables ceramide kinase activity	ISO Inferred from Sequence Orthology more info
enables lipid kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingolipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info