Commd6 COMM domain containing 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Commd6provided by RGD
Official Full Name: COMM domain containing 6provided by RGD
Primary source: RGD:1560745
See related: EnsemblRapid:ENSRNOG00000038012 AllianceGenome:RGD:1560745
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560745
Summary: Predicted to enable NF-kappaB binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of NF-kappaB transcription factor activity. Orthologous to human COMMD6 (COMM domain containing 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 61.7), Thymus (RPKM 61.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (84882069..84889124, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (78467333..78474382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (86136096..86142672, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134357 (e-PCR)
- UniSTS:217639

AA850154 (e-PCR)
- UniSTS:250268

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: COMM domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109105.1 → NP_001102575.1 COMM domain-containing protein 6

Status: PROVISIONAL

Source sequence(s)

CH473951

UniProtKB/TrEMBL

A6HU73, D4A8E7

Related

ENSRNOP00000054640.2, ENSRNOT00000057830.4

Conserved Domains (1) summary

cl06336
Location:29 → 106

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...