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    Brat1 BRCA1-associated ATM activator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498150, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Brat1provided by RGD
    Official Full Name
    BRCA1-associated ATM activator 1provided by RGD
    Primary source
    RGD:1565146
    See related
    EnsemblRapid:ENSRNOG00000001236 AllianceGenome:RGD:1565146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brat1-ps1; RGD1565146
    Summary
    Predicted to be involved in several processes, including positive regulation of cell growth; positive regulation of protein phosphorylation; and response to ionizing radiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human BRAT1 (BRCA1 associated ATM activator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 47.7), Thymus (RPKM 47.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Brat1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19043004..19065686, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13928889..13951760, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16016062..16028534, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene IQ motif containing E Neighboring gene tweety family member 3 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction. So EY, et al. BMC Cancer, 2014 Jul 29. PMID 25070371, Free PMC Article
    2. The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR. So EY, et al. J Cancer Biol Res, 2013 Jul-Aug. PMID 25657994, Free PMC Article
    3. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. Aglipay JA, et al. J Biol Chem, 2006 Apr 7. PMID 16452482
    4. Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit. So EY, et al. Exp Ther Med, 2011 May. PMID 22977523, Free PMC Article
    5. Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. Low LH, et al. J Biol Chem, 2015 Mar 13. PMID 25631046, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BRCA1-associated ATM activator 1
    Names
    BRCA1-associated ATM activator 1, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431849.1 → NP_001418778.1  BRCA1-associated ATM activator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1R4, D3ZSM9

    2. NM_001431850.1 → NP_001418779.1  BRCA1-associated ATM activator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1R4, D3ZSM9

    3. NM_001431851.1 → NP_001418780.1  BRCA1-associated ATM activator 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1R4

    4. NM_001431852.1 → NP_001418781.1  BRCA1-associated ATM activator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6A979, A6K1R4

    5. NM_001431853.1 → NP_001418782.1  BRCA1-associated ATM activator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6A979, A6K1R4

    6. NM_001431854.1 → NP_001418783.1  BRCA1-associated ATM activator 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    7. NM_001431855.1 → NP_001418784.1  BRCA1-associated ATM activator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    8. NM_001431856.1 → NP_001418785.1  BRCA1-associated ATM activator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19043004..19065686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089962.2 → XP_038945890.1  BRCA1-associated ATM activator 1 isoform X1

      UniProtKB/TrEMBL
      A6K1R4, D3ZSM9
      Conserved Domains (1) summary
      sd00044
      Location:501 → 529
      HEAT; HEAT repeat [structural motif]

    2. XM_039089965.2 → XP_038945893.1  BRCA1-associated ATM activator 1 isoform X5

    3. XM_017598487.3 → XP_017453976.1  BRCA1-associated ATM activator 1 isoform X2

      Related
      ENSRNOP00000105329.1, ENSRNOT00000161004.1

    4. XM_006248968.4 → XP_006249030.1  BRCA1-associated ATM activator 1 isoform X1

      Conserved Domains (1) summary
      sd00044
      Location:501 → 529
      HEAT; HEAT repeat [structural motif]

    5. XM_003751133.3 → XP_003751181.1  BRCA1-associated ATM activator 1 isoform X1

      Related
      ENSRNOP00000059762.3, ENSRNOT00000064726.5
      Conserved Domains (1) summary
      sd00044
      Location:501 → 529
      HEAT; HEAT repeat [structural motif]

    6. XM_039089964.2 → XP_038945892.1  BRCA1-associated ATM activator 1 isoform X4

      Conserved Domains (1) summary
      sd00044
      Location:326 → 354
      HEAT; HEAT repeat [structural motif]

    7. XM_063271873.1 → XP_063127943.1  BRCA1-associated ATM activator 1 isoform X3

      Related
      ENSRNOP00000089150.1, ENSRNOT00000097546.2

    8. XM_063271874.1 → XP_063127944.1  BRCA1-associated ATM activator 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A979, A6K1R4

    9. XM_063271875.1 → XP_063127945.1  BRCA1-associated ATM activator 1 isoform X6

      UniProtKB/TrEMBL
      A6K1R6
    Nucleotide Protein Strain
    Heading Accession and Version

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