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    Zfp131 zinc finger protein 131 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310375, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfp131provided by RGD
    Official Full Name
    zinc finger protein 131provided by RGD
    Primary source
    RGD:1307638
    See related
    EnsemblRapid:ENSRNOG00000015925 AllianceGenome:RGD:1307638
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of cytokine production; regulation of immune system process; and regulation of transcription by RNA polymerase II. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in nucleoplasm. Orthologous to human ZNF131 (zinc finger protein 131). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 150.5), Spleen (RPKM 108.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp131 in Genome Data Viewer
    Location:
    2q15-q16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (53457893..53486348, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51722774..51753662, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52503185..52532097, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547360 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 1 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene uncharacterized LOC134485849 Neighboring gene RNA, U6 small nuclear 446 Neighboring gene zinc finger protein 131 like 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4, pseudogene 3 Neighboring gene uncharacterized LOC134485779

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kaiso regulates Znf131-mediated transcriptional activation. Donaldson NS, et al. Exp Cell Res, 2010 Jun 10. PMID 20303951
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 131

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100698.2 → NP_001094168.1  zinc finger protein 131

      See identical proteins and their annotated locations for NP_001094168.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      B1WC22, F7FPM3
      Related
      ENSRNOP00000021608.4, ENSRNOT00000021608.8
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      53457893..53486348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281778.1 → XP_063137848.1  zinc finger protein 131 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX21, A0A8I6AC93, A6I5X1

    2. XM_006231960.5 → XP_006232022.1  zinc finger protein 131 isoform X1

      See identical proteins and their annotated locations for XP_006232022.1

      UniProtKB/TrEMBL
      B1WC22, F7FPM3
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063281781.1 → XP_063137851.1  zinc finger protein 131 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX21, A0A8I6AC93, A6I5X1

    4. XM_006231963.5 → XP_006232025.1  zinc finger protein 131 isoform X1

      See identical proteins and their annotated locations for XP_006232025.1

      UniProtKB/TrEMBL
      B1WC22, F7FPM3
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063281780.1 → XP_063137850.1  zinc finger protein 131 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX21, A0A8I6AC93, A6I5X1
      Related
      ENSRNOP00000070103.1, ENSRNOT00000089303.3

    6. XM_006231962.5 → XP_006232024.1  zinc finger protein 131 isoform X1

      See identical proteins and their annotated locations for XP_006232024.1

      UniProtKB/TrEMBL
      B1WC22, F7FPM3
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    7. XM_063281779.1 → XP_063137849.1  zinc finger protein 131 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX21, A0A8I6AC93, A6I5X1

    8. XM_006231961.5 → XP_006232023.1  zinc finger protein 131 isoform X1

      See identical proteins and their annotated locations for XP_006232023.1

      UniProtKB/TrEMBL
      B1WC22, F7FPM3
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    9. XM_063281782.1 → XP_063137852.1  zinc finger protein 131 isoform X3

    10. XM_039102253.2 → XP_038958181.1  zinc finger protein 131 isoform X4

      Conserved Domains (3) summary
      sd00017
      Location:11 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:143 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:63 → 88
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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