G6pd glucose-6-phosphate dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: G6pdprovided by RGD
Official Full Name: glucose-6-phosphate dehydrogenaseprovided by RGD
Primary source: RGD:2645
See related: EnsemblRapid:ENSRNOG00000056728 AllianceGenome:RGD:2645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: G6pdx
Summary: Enables D-glucose binding activity; NADP binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; pentose-phosphate shunt, oxidative branch; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic side of plasma membrane; and intracellular membrane-bounded organelle. Predicted to be active in cytosol. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); hepatic encephalopathy; hyperhomocysteinemia; liver disease (multiple); and phenylketonuria. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 616.1), Thymus (RPKM 246.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157352364..157372144, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152201081..152220863, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156274800..156293935)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats.
Title: Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats.
G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall.
Title: G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall.
Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension.
Title: Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension.
HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression.
Title: HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression.
G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
Title: G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
an investigation was carried out regarding the inhibitory effects caused by various metal ions (Fe(2+) , Pb(2+) , Cd(2+) , Ag(+) , and Zn(2+) ) on G6PD enzyme activities, as per Beutler method at 340 nm under in vitro conditions. Lineweaver-Burk diagrams were used for estimation of the IC50 and Ki values for the metals. Ki values for Pb(+2) , Cd(+2) , Ag(+) , and Zn(+2) were 113.3, 215.2, 19.4, and 474.7 muM, respectiv...
Title: Purification of glucose-6-phosphate dehydrogenase from rat (Rattus norvegicus) erythrocytes and inhibition effects of some metal ions on enzyme activity.
20-HETE elicited mitochondrial superoxide production and promoted secretory phenotype of vascular smooth muscle cells by activating MAPK1-Elk-1, all of which are blocked by inhibition of G6PD.
Title: 20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
Examination of changes in enzyme activities of erythrocyte glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in rats given Naringenin and Lead acetate.
Title: Examination of changes in enzyme activities of erythrocyte glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in rats given Naringenin and Lead acetate.
Data show that intake of the Livingstone potato (Plectranthus esculentus N.E.Br) feed by the diabetic rats resulted in significant amelioration of hepatic glucose-6-phosphophate dehydrogenase activity in comparison with the diabetic control.
Title: Effect of Livingstone potato (Plectranthus esculentus N.E.Br) on hepatic glucose-6-phosphophate dehydrogenase activity of streptozotocin induced diabetic rats.
Glucose-6-phosphate dehydrogenase alleviated the signs of behavioural and biochemical effects of AlCl3-treatment suggesting its involvement in the pathogenesis of Aluminum neurotoxicity and its potential therapeutic benefit.
Title: Protective effects of glucose-6-phosphate dehydrogenase on neurotoxicity of aluminium applied into the CA1 sector of rat hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142193 (e-PCR)
- UniSTS:231443

BI284751 (e-PCR)
- UniSTS:244251

PMC85812P2 (e-PCR)
- UniSTS:273495

NoName (e-PCR)
- UniSTS:491414

UniSTS:256936 (e-PCR)
- UniSTS:256936

G6pdx (e-PCR), detects polymorphism
- UniSTS:256936

PMC311070P2 (e-PCR)
- UniSTS:272892

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose binding	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables D-glucose binding	ISO Inferred from Sequence Orthology more info
enables NADP binding	IDA Inferred from Direct Assay more info	PubMed
enables NADP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NADP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in NADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in NADPH regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose 6-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein glutathionylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pentose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pentose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt	IDA Inferred from Direct Assay more info	PubMed
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose-phosphate shunt, oxidative branch	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron(III) ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in ribose phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucose-6-phosphate 1-dehydrogenase

Names: glucose-6-phosphate dehydrogenase X-linked

NP_058702.1

EC 1.1.1.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.