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    Gata3 GATA binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85471, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gata3provided by RGD
    Official Full Name
    GATA binding protein 3provided by RGD
    Primary source
    RGD:621250
    See related
    EnsemblRapid:ENSRNOG00000019336 AllianceGenome:RGD:621250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-binding transcription factor activity; histone methyltransferase binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cochlea development; response to gamma radiation; and type IV hypersensitivity. Predicted to be located in chromatin and nucleoplasm. Predicted to be active in nucleus. Biomarker of asthma. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 42.6), Kidney (RPKM 29.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Gata3 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (73544234..73575670)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (68643760..68666000)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (72419752..72452043)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102546431 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene uncharacterized LOC120097843 Neighboring gene uncharacterized LOC134482600 Neighboring gene uncharacterized LOC102546657 Neighboring gene uncharacterized LOC120097778

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables E-box binding  
    enables HMG box domain binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables histone methyltransferase binding PubMed 
    enables identical protein binding  
    enables interleukin-2 receptor binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription coactivator binding  
    enables zinc ion binding  
    Items 1 - 25 of 118
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell differentiation  
    acts_upstream_of_or_within T cell differentiation in thymus  
    involved_in T cell receptor signaling pathway  
    acts_upstream_of_or_within T-helper 2 cell differentiation  
    involved_in T-helper 2 cell differentiation  
    involved_in TOR signaling  
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis  
    involved_in aortic valve morphogenesis  
    acts_upstream_of_or_within axon guidance  
    involved_in canonical Wnt signaling pathway  
    involved_in cardiac right ventricle morphogenesis  
    involved_in cartilage development  
    acts_upstream_of_or_within cell activation  
    acts_upstream_of_or_within cell fate determination  
    acts_upstream_of_or_within cell maturation  
    acts_upstream_of_or_within cell morphogenesis  
    acts_upstream_of cell population proliferation  
    acts_upstream_of_or_within cellular response to BMP stimulus  
    acts_upstream_of_or_within cellular response to cytokine stimulus  
    involved_in cellular response to interferon-alpha  
    acts_upstream_of_or_within cellular response to interleukin-4  
    involved_in cellular response to interleukin-4  
    involved_in cellular response to tumor necrosis factor  
    acts_upstream_of_or_within chromatin remodeling  
    involved_in cochlea development PubMed 
    acts_upstream_of_or_within developmental growth  
    involved_in ear development  
    acts_upstream_of_or_within embryonic hemopoiesis  
    acts_upstream_of_or_within embryonic organ development  
    acts_upstream_of_or_within erythrocyte differentiation  
    involved_in gene expression  
    acts_upstream_of_or_within homeostasis of number of cells  
    acts_upstream_of_or_within humoral immune response  
    acts_upstream_of_or_within in utero embryonic development  
    involved_in inflammatory response  
    acts_upstream_of_or_within inner ear morphogenesis  
    involved_in kidney development  
    acts_upstream_of_or_within lens development in camera-type eye  
    involved_in lymphocyte migration  
    involved_in macrophage differentiation  
    involved_in male gonad development  
    acts_upstream_of_or_within mast cell differentiation  
    involved_in mesenchymal to epithelial transition  
    acts_upstream_of_or_within mesonephros development  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of cell cycle  
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell motility  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of cell proliferation involved in mesonephros development  
    involved_in negative regulation of endothelial cell apoptotic process  
    acts_upstream_of negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation  
    acts_upstream_of_or_within negative regulation of gene expression  
    involved_in negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation  
    involved_in negative regulation of inflammatory response  
    acts_upstream_of_or_within negative regulation of interleukin-2 production  
    involved_in negative regulation of mammary gland epithelial cell proliferation  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of type II interferon production  
    involved_in nephric duct formation  
    involved_in nephric duct morphogenesis  
    acts_upstream_of_or_within nervous system development  
    acts_upstream_of_or_within neuron differentiation  
    acts_upstream_of_or_within neuron migration  
    acts_upstream_of_or_within norepinephrine biosynthetic process  
    acts_upstream_of_or_within otic vesicle development  
    acts_upstream_of_or_within parathyroid gland development  
    acts_upstream_of_or_within parathyroid hormone secretion  
    involved_in pharyngeal system development  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of T cell differentiation  
    acts_upstream_of_or_within positive regulation of T-helper 2 cell cytokine production  
    acts_upstream_of_or_within positive regulation of cell differentiation  
    acts_upstream_of_or_within positive regulation of cytokine production  
    involved_in positive regulation of endothelial cell migration  
    acts_upstream_of_or_within positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of interleukin-13 production  
    involved_in positive regulation of interleukin-13 production  
    acts_upstream_of_or_within positive regulation of interleukin-4 production  
    acts_upstream_of_or_within positive regulation of interleukin-5 production  
    involved_in positive regulation of interleukin-5 production  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of signal transduction  
    involved_in positive regulation of thyroid hormone generation  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of ureteric bud formation  
    acts_upstream_of_or_within post-embryonic development  
    acts_upstream_of_or_within pro-T cell differentiation  
    acts_upstream_of_or_within regulation of T-helper cell differentiation  
    involved_in regulation of cellular response to X-ray  
    acts_upstream_of_or_within regulation of cytokine production  
    acts_upstream_of_or_within regulation of establishment of cell polarity  
    involved_in regulation of nephron tubule epithelial cell differentiation  
    acts_upstream_of_or_within regulation of neuron apoptotic process  
    acts_upstream_of_or_within regulation of neuron projection development  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in response to estrogen  
    involved_in response to ethanol PubMed 
    involved_in response to gamma radiation PubMed 
    involved_in response to virus  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    acts_upstream_of_or_within sympathetic nervous system development  
    acts_upstream_of_or_within thymic T cell selection  
    acts_upstream_of_or_within thymus development  
    acts_upstream_of transcription by RNA polymerase II  
    involved_in type IV hypersensitivity PubMed 
    acts_upstream_of_or_within ureter maturation  
    acts_upstream_of_or_within ureter morphogenesis  
    involved_in ureteric bud formation  
    involved_in uterus development  
    involved_in ventricular septum development  
    Items 1 - 25 of 118
    Component Evidence Code Pubs
    located_in chromatin  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    trans-acting T-cell-specific transcription factor GATA-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133293.3NP_579827.1  trans-acting T-cell-specific transcription factor GATA-3

      See identical proteins and their annotated locations for NP_579827.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5
      Related
      ENSRNOP00000026187.3, ENSRNOT00000026187.7
      Conserved Domains (1) summary
      cd00202
      Location:317367
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      73544234..73575670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276782.1XP_063132852.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5
    2. XM_063276783.1XP_063132853.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6L1
    3. XM_017600667.3XP_017456156.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6L1
      Conserved Domains (1) summary
      cd00202
      Location:316366
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    4. XM_063276784.1XP_063132854.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X3

    5. XM_063276785.1XP_063132855.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X4

    6. XM_008771893.3XP_008770115.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X1

      See identical proteins and their annotated locations for XP_008770115.1

      UniProtKB/TrEMBL
      A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5
      Conserved Domains (1) summary
      cd00202
      Location:317367
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
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