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    Ctnnb1 catenin beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84353, updated on 10-Dec-2024

    Summary

    Official Symbol
    Ctnnb1provided by RGD
    Official Full Name
    catenin beta 1provided by RGD
    Primary source
    RGD:70487
    See related
    EnsemblRapid:ENSRNOG00000054172 AllianceGenome:RGD:70487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Catnb
    Summary
    Enables several functions, including alpha-catenin binding activity; delta-catenin binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; and cellular response to mechanical stimulus. Located in several cellular components, including dendritic shaft; intercalated disc; and lateral plasma membrane. Part of protein-containing complex. Used to study colon adenocarcinoma and lung carcinoma. Biomarker of Alzheimer's disease and colorectal cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1354.8), Lung (RPKM 1330.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ctnnb1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (129517576..129544661)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (120640008..120667110)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (129601511..129628378)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480116 Neighboring gene uncharacterized LOC102550417 Neighboring gene unc-51 like kinase 4 Neighboring gene uncharacterized LOC134480250 Neighboring gene uncharacterized LOC120094299

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 50
    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables I-SMAD binding  
    enables I-SMAD binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables SMAD binding  
    enables alpha-catenin binding  
    enables alpha-catenin binding  
    enables alpha-catenin binding PubMed 
    enables alpha-catenin binding  
    enables cadherin binding  
    enables cadherin binding PubMed 
    enables cadherin binding  
    enables cadherin binding PubMed 
    enables cadherin binding  
    enables chromatin binding  
    enables chromatin binding  
    enables delta-catenin binding PubMed 
    enables disordered domain specific binding  
    enables disordered domain specific binding  
    enables enzyme binding  
    enables histone methyltransferase binding  
    enables ionotropic glutamate receptor binding PubMed 
    enables kinase binding  
    enables molecular function activator activity  
    enables nitric-oxide synthase binding PubMed 
    enables nuclear estrogen receptor binding  
    enables nuclear estrogen receptor binding  
    enables nuclear receptor binding  
    enables nuclear receptor binding  
    enables nucleic acid binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein-containing complex binding PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coregulator binding  
    enables transcription corepressor binding  
    enables transcription corepressor binding  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 50
    Items 1 - 25 of 393
    Process Evidence Code Pubs
    acts_upstream_of DNA-templated transcription  
    involved_in MAPK cascade  
    acts_upstream_of MAPK cascade  
    involved_in Schwann cell proliferation PubMed 
    acts_upstream_of_or_within T cell differentiation  
    involved_in T cell differentiation in thymus  
    acts_upstream_of_or_within T cell differentiation in thymus  
    involved_in acinar cell differentiation  
    acts_upstream_of_or_within acinar cell differentiation  
    involved_in adherens junction assembly  
    involved_in adherens junction assembly  
    involved_in adherens junction assembly  
    acts_upstream_of_or_within adherens junction organization  
    acts_upstream_of_or_within animal organ development  
    involved_in anterior/posterior axis specification  
    acts_upstream_of_or_within anterior/posterior axis specification  
    involved_in apoptotic signaling pathway  
    acts_upstream_of apoptotic signaling pathway  
    involved_in astrocyte-dopaminergic neuron signaling  
    involved_in astrocyte-dopaminergic neuron signaling  
    involved_in bicellular tight junction assembly  
    involved_in bone remodeling PubMed 
    involved_in bone resorption  
    acts_upstream_of_or_within bone resorption  
    involved_in branching involved in blood vessel morphogenesis  
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis  
    involved_in branching involved in blood vessel morphogenesis  
    involved_in branching involved in ureteric bud morphogenesis  
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis  
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  
    involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell adhesion PubMed 
    acts_upstream_of cell differentiation  
    involved_in cell fate specification  
    acts_upstream_of_or_within cell fate specification  
    involved_in cell maturation  
    acts_upstream_of_or_within cell maturation  
    acts_upstream_of_or_within cell morphogenesis  
    acts_upstream_of cell population proliferation  
    acts_upstream_of_or_within cell population proliferation  
    involved_in cell-cell adhesion  
    involved_in cell-cell adhesion PubMed 
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-cell adhesion  
    involved_in cell-cell adhesion  
    involved_in cell-cell adhesion PubMed 
    involved_in cell-cell adhesion mediated by cadherin  
    involved_in cell-matrix adhesion  
    acts_upstream_of_or_within cell-matrix adhesion  
    involved_in cellular response to fibroblast growth factor stimulus PubMed 
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to indole-3-methanol  
    involved_in cellular response to indole-3-methanol  
    involved_in cellular response to indole-3-methanol  
    involved_in cellular response to insulin-like growth factor stimulus PubMed 
    involved_in cellular response to insulin-like growth factor stimulus PubMed 
    involved_in cellular response to lithium ion PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to zinc ion starvation PubMed 
    involved_in central nervous system vasculogenesis  
    acts_upstream_of_or_within central nervous system vasculogenesis  
    involved_in chemical synaptic transmission  
    acts_upstream_of_or_within chemical synaptic transmission  
    involved_in chondrocyte differentiation  
    acts_upstream_of chondrocyte differentiation  
    involved_in cranial ganglion development  
    involved_in cranial ganglion development  
    involved_in cranial skeletal system development  
    involved_in cranial skeletal system development  
    involved_in dorsal root ganglion development  
    involved_in dorsal root ganglion development  
    involved_in dorsal/ventral axis specification  
    acts_upstream_of_or_within dorsal/ventral axis specification  
    acts_upstream_of_or_within dorsal/ventral pattern formation  
    involved_in ectoderm development  
    acts_upstream_of_or_within ectoderm development  
    involved_in embryonic axis specification  
    acts_upstream_of_or_within embryonic axis specification  
    involved_in embryonic brain development  
    involved_in embryonic brain development  
    involved_in embryonic digit morphogenesis  
    acts_upstream_of_or_within embryonic digit morphogenesis  
    involved_in embryonic foregut morphogenesis  
    acts_upstream_of_or_within embryonic foregut morphogenesis  
    involved_in embryonic forelimb morphogenesis  
    acts_upstream_of_or_within embryonic forelimb morphogenesis  
    involved_in embryonic heart tube development  
    acts_upstream_of_or_within embryonic heart tube development  
    involved_in embryonic hindlimb morphogenesis  
    acts_upstream_of_or_within embryonic hindlimb morphogenesis  
    involved_in embryonic organ development  
    involved_in embryonic skeletal limb joint morphogenesis  
    involved_in embryonic skeletal limb joint morphogenesis  
    acts_upstream_of_or_within endoderm formation  
    involved_in endodermal cell fate commitment  
    acts_upstream_of_or_within endodermal cell fate commitment  
    involved_in endothelial tube morphogenesis  
    involved_in endothelial tube morphogenesis  
    involved_in endothelial tube morphogenesis  
    involved_in epididymis development PubMed 
    involved_in epithelial cell differentiation involved in prostate gland development  
    acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development  
    involved_in epithelial cell proliferation involved in prostate gland development  
    acts_upstream_of epithelial cell proliferation involved in prostate gland development  
    involved_in epithelial tube branching involved in lung morphogenesis  
    acts_upstream_of epithelial tube branching involved in lung morphogenesis  
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis  
    involved_in establishment of blood-brain barrier  
    acts_upstream_of_or_within establishment of blood-brain barrier  
    involved_in establishment of blood-retinal barrier  
    acts_upstream_of_or_within establishment of blood-retinal barrier  
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within forebrain development  
    involved_in fungiform papilla formation  
    acts_upstream_of_or_within fungiform papilla formation  
    involved_in gastrulation with mouth forming second  
    acts_upstream_of_or_within gastrulation with mouth forming second  
    acts_upstream_of_or_within gene expression  
    involved_in genitalia morphogenesis  
    acts_upstream_of_or_within genitalia morphogenesis  
    acts_upstream_of_or_within glandular epithelial cell differentiation  
    involved_in glial cell fate determination  
    acts_upstream_of_or_within glial cell fate determination  
    acts_upstream_of_or_within hair cycle process  
    involved_in hair follicle morphogenesis  
    acts_upstream_of_or_within hair follicle morphogenesis  
    involved_in hair follicle placode formation  
    acts_upstream_of_or_within hair follicle placode formation  
    acts_upstream_of_or_within heart development  
    acts_upstream_of_or_within hemopoiesis  
    involved_in hindbrain development  
    involved_in hindbrain development  
    involved_in hypothalamus development  
    involved_in hypothalamus development  
    involved_in in utero embryonic development  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within kidney development  
    involved_in layer formation in cerebral cortex  
    acts_upstream_of_or_within layer formation in cerebral cortex  
    involved_in lens morphogenesis in camera-type eye  
    acts_upstream_of_or_within lens morphogenesis in camera-type eye  
    acts_upstream_of_or_within limb development  
    involved_in liver development PubMed 
    acts_upstream_of_or_within lung cell differentiation  
    acts_upstream_of_or_within lung development  
    involved_in lung epithelial cell differentiation  
    acts_upstream_of lung epithelial cell differentiation  
    involved_in lung induction  
    acts_upstream_of_or_within lung induction  
    involved_in lung-associated mesenchyme development  
    acts_upstream_of_or_within lung-associated mesenchyme development  
    involved_in male genitalia development  
    acts_upstream_of_or_within male genitalia development  
    acts_upstream_of mesenchymal cell proliferation  
    involved_in mesenchymal cell proliferation involved in lung development  
    acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development  
    involved_in mesenchymal stem cell differentiation  
    involved_in metanephros morphogenesis  
    acts_upstream_of_or_within metanephros morphogenesis  
    involved_in midbrain development  
    involved_in midbrain dopaminergic neuron differentiation  
    involved_in midbrain dopaminergic neuron differentiation  
    involved_in midgut development PubMed 
    acts_upstream_of_or_within morphogenesis of embryonic epithelium  
    involved_in myoblast differentiation PubMed 
    involved_in myoblast proliferation  
    acts_upstream_of myoblast proliferation  
    acts_upstream_of_or_within myoblast proliferation  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of cell differentiation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of chondrocyte differentiation  
    acts_upstream_of_or_within negative regulation of chondrocyte differentiation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  
    acts_upstream_of_or_within negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  
    involved_in negative regulation of mitotic cell cycle, embryonic  
    involved_in negative regulation of mitotic cell cycle, embryonic  
    involved_in negative regulation of mitotic cell cycle, embryonic  
    involved_in negative regulation of neurogenesis  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process  
    involved_in negative regulation of oligodendrocyte differentiation  
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation  
    involved_in negative regulation of osteoclast differentiation  
    acts_upstream_of_or_within negative regulation of osteoclast differentiation  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of protein sumoylation  
    involved_in negative regulation of protein sumoylation  
    involved_in negative regulation of protein sumoylation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in nephron tubule formation  
    acts_upstream_of_or_within nephron tubule formation  
    involved_in neural plate development  
    acts_upstream_of_or_within neural plate development  
    involved_in neuroblast proliferation  
    acts_upstream_of neuroblast proliferation  
    involved_in neuron differentiation  
    involved_in neuron fate determination  
    acts_upstream_of_or_within neuron fate determination  
    involved_in neuron migration  
    acts_upstream_of_or_within neuron migration  
    involved_in neuron projection extension  
    involved_in neuron projection extension  
    involved_in neuron projection extension  
    involved_in odontogenesis of dentin-containing tooth  
    involved_in odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth  
    involved_in oligodendrocyte differentiation  
    acts_upstream_of oligodendrocyte differentiation  
    involved_in oocyte development  
    acts_upstream_of_or_within oocyte development  
    involved_in osteoblast differentiation  
    acts_upstream_of osteoblast differentiation  
    involved_in osteoblast differentiation  
    involved_in osteoclast differentiation  
    acts_upstream_of osteoclast differentiation  
    acts_upstream_of_or_within osteoclast differentiation  
    involved_in outflow tract morphogenesis  
    involved_in outflow tract morphogenesis  
    involved_in oviduct development  
    acts_upstream_of_or_within oviduct development  
    involved_in pancreas development  
    acts_upstream_of_or_within pancreas development  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of branching involved in lung morphogenesis  
    acts_upstream_of_or_within positive regulation of branching involved in lung morphogenesis  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of determination of dorsal identity  
    acts_upstream_of_or_within positive regulation of determination of dorsal identity  
    involved_in positive regulation of endothelial cell differentiation  
    acts_upstream_of_or_within positive regulation of endothelial cell differentiation  
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation  
    involved_in positive regulation of epithelial cell proliferation involved in prostate gland development  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development  
    involved_in positive regulation of epithelial to mesenchymal transition  
    acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway  
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process  
    involved_in positive regulation of mesenchymal cell proliferation  
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation  
    involved_in positive regulation of molecular function  
    involved_in positive regulation of myoblast proliferation  
    acts_upstream_of_or_within positive regulation of myoblast proliferation  
    involved_in positive regulation of neural precursor cell proliferation  
    involved_in positive regulation of neuroblast proliferation  
    acts_upstream_of_or_within positive regulation of neuroblast proliferation  
    involved_in positive regulation of neuroblast proliferation  
    involved_in positive regulation of neuroblast proliferation  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of odontoblast differentiation  
    involved_in positive regulation of odontoblast differentiation  
    involved_in positive regulation of osteoblast differentiation  
    acts_upstream_of_or_within positive regulation of osteoblast differentiation  
    involved_in positive regulation of skeletal muscle tissue development  
    involved_in positive regulation of skeletal muscle tissue development  
    involved_in positive regulation of stem cell proliferation  
    acts_upstream_of_or_within positive regulation of stem cell proliferation  
    involved_in positive regulation of telomere maintenance via telomerase  
    acts_upstream_of positive regulation of telomere maintenance via telomerase  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription elongation by RNA polymerase II  
    involved_in positive regulation of transcription elongation by RNA polymerase II  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within protein localization  
    involved_in protein localization to cell surface  
    involved_in protein localization to cell surface  
    involved_in protein localization to cell surface  
    involved_in protein polyubiquitination  
    involved_in protein polyubiquitination  
    involved_in proximal/distal pattern formation  
    acts_upstream_of_or_within proximal/distal pattern formation  
    involved_in regulation of T cell proliferation  
    acts_upstream_of_or_within regulation of T cell proliferation  
    acts_upstream_of_or_within regulation of apoptotic process  
    involved_in regulation of calcium ion import  
    involved_in regulation of calcium ion import  
    involved_in regulation of calcium ion import  
    acts_upstream_of_or_within regulation of cell differentiation  
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in regulation of centriole-centriole cohesion  
    involved_in regulation of centriole-centriole cohesion  
    involved_in regulation of centriole-centriole cohesion  
    involved_in regulation of centromeric sister chromatid cohesion  
    involved_in regulation of centromeric sister chromatid cohesion  
    involved_in regulation of centromeric sister chromatid cohesion  
    acts_upstream_of_or_within regulation of epithelial cell differentiation  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of myelination  
    acts_upstream_of_or_within regulation of myelination  
    involved_in regulation of nephron tubule epithelial cell differentiation  
    involved_in regulation of nephron tubule epithelial cell differentiation  
    acts_upstream_of_or_within regulation of osteoblast differentiation  
    acts_upstream_of_or_within regulation of osteoclast differentiation  
    involved_in regulation of protein localization to cell surface  
    involved_in regulation of protein localization to cell surface  
    involved_in regulation of protein localization to cell surface  
    involved_in regulation of protein ubiquitination  
    involved_in regulation of protein ubiquitination  
    involved_in regulation of secondary heart field cardioblast proliferation  
    acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation  
    involved_in regulation of smooth muscle cell proliferation  
    involved_in regulation of smooth muscle cell proliferation  
    involved_in regulation of smooth muscle cell proliferation  
    involved_in regulation of synapse assembly  
    involved_in regulation of synapse assembly  
    involved_in regulation of timing of anagen  
    involved_in regulation of timing of anagen  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in renal inner medulla development  
    acts_upstream_of_or_within renal inner medulla development  
    involved_in renal outer medulla development  
    acts_upstream_of_or_within renal outer medulla development  
    involved_in renal vesicle formation  
    acts_upstream_of_or_within renal vesicle formation  
    involved_in response to activity PubMed 
    involved_in response to cadmium ion PubMed 
    involved_in response to cytokine PubMed 
    involved_in response to estradiol  
    involved_in response to estradiol PubMed 
    involved_in response to estradiol  
    involved_in response to estradiol  
    involved_in response to estrogen PubMed 
    involved_in response to hormone PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in response to xenobiotic stimulus  
    acts_upstream_of_or_within skeletal system development  
    acts_upstream_of_or_within skin development  
    involved_in smooth muscle cell differentiation  
    acts_upstream_of_or_within smooth muscle cell differentiation  
    involved_in stem cell proliferation  
    acts_upstream_of stem cell proliferation  
    involved_in sympathetic ganglion development  
    involved_in sympathetic ganglion development  
    involved_in sympathetic ganglion development  
    involved_in synapse organization  
    acts_upstream_of_or_within synapse organization  
    involved_in synaptic vesicle clustering  
    involved_in synaptic vesicle clustering  
    involved_in synaptic vesicle transport  
    acts_upstream_of_or_within synaptic vesicle transport  
    involved_in thymus development  
    acts_upstream_of_or_within thymus development  
    acts_upstream_of_or_within tissue homeostasis  
    involved_in trachea formation  
    acts_upstream_of_or_within trachea formation  
    acts_upstream_of_or_within trachea morphogenesis  
    involved_in transcription by RNA polymerase II  
    acts_upstream_of transcription by RNA polymerase II  
    acts_upstream_of_or_within vasculature development  
    acts_upstream_of_or_within vasculogenesis  
    Items 1 - 25 of 393
    Items 1 - 20 of 109
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    part_of Scrib-APC-beta-catenin complex  
    part_of Scrib-APC-beta-catenin complex  
    part_of Wnt signalosome  
    part_of Wnt signalosome  
    located_in Z disc  
    located_in Z disc  
    is_active_in adherens junction  
    located_in adherens junction PubMed 
    located_in adherens junction  
    located_in adherens junction  
    located_in apical junction complex  
    located_in apical part of cell  
    located_in apical part of cell  
    located_in apical plasma membrane PubMed 
    located_in apicolateral plasma membrane  
    located_in apicolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    part_of beta-catenin destruction complex  
    part_of beta-catenin destruction complex  
    part_of beta-catenin destruction complex  
    part_of beta-catenin-ICAT complex  
    part_of beta-catenin-ICAT complex  
    part_of beta-catenin-TCF complex  
    part_of beta-catenin-TCF7L2 complex  
    part_of beta-catenin-TCF7L2 complex  
    part_of beta-catenin-TCF7L2 complex  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    part_of catenin complex  
    part_of catenin complex  
    part_of catenin complex  
    part_of catenin complex  
    located_in cell cortex  
    located_in cell cortex  
    located_in cell junction  
    located_in cell junction  
    located_in cell periphery  
    located_in cell periphery  
    located_in cell projection membrane  
    located_in cell-cell junction  
    located_in cell-cell junction  
    located_in centrosome  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendritic shaft PubMed 
    located_in euchromatin  
    located_in euchromatin  
    located_in exocytic vesicle  
    located_in fascia adherens  
    located_in fascia adherens  
    part_of flotillin complex  
    part_of flotillin complex  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in intercalated disc PubMed 
    located_in intercalated disc  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lateral plasma membrane PubMed 
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    located_in membrane PubMed 
    located_in membrane  
    located_in microvillus membrane  
    located_in microvillus membrane  
    located_in nuclear membrane PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density, intracellular component  
    is_active_in postsynaptic density, intracellular component  
    located_in postsynaptic membrane  
    is_active_in postsynaptic membrane  
    located_in presynaptic active zone cytoplasmic component  
    is_active_in presynaptic active zone cytoplasmic component  
    located_in presynaptic membrane  
    is_active_in presynaptic membrane  
    part_of protein-DNA complex  
    part_of protein-DNA complex  
    part_of protein-DNA complex  
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    located_in spindle pole  
    located_in synapse  
    located_in tight junction PubMed 
    part_of transcription regulator complex  
    part_of transcription regulator complex  
    Items 1 - 20 of 109

    General protein information

    Preferred Names
    catenin beta-1
    Names
    beta-catenin
    catenin (cadherin associated protein), beta 1, 88kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431656.1NP_001418585.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    2. NM_001431662.1NP_001418591.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    3. NM_001431663.1NP_001418592.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    4. NM_001431664.1NP_001418593.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    5. NM_001431665.1NP_001418594.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    6. NM_001431666.1NP_001418595.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    7. NM_001431667.1NP_001418596.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    8. NM_001431668.1NP_001418597.1  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428
    9. NM_053357.3NP_445809.3  catenin beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WU82
      UniProtKB/TrEMBL
      A0A0G2JT93, A6I428

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      129517576..129544661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266229.1XP_063122299.1  catenin beta-1 isoform X1

    2. XM_039082208.2XP_038938136.1  catenin beta-1 isoform X1

      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    3. XM_039082209.2XP_038938137.1  catenin beta-1 isoform X1

      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    4. XM_039082207.2XP_038938135.1  catenin beta-1 isoform X1

      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    5. XM_063266226.1XP_063122296.1  catenin beta-1 isoform X1

    6. XM_063266224.1XP_063122294.1  catenin beta-1 isoform X1

      Related
      ENSRNOP00000094665.2, ENSRNOT00000101345.2
    7. XM_063266227.1XP_063122297.1  catenin beta-1 isoform X1

    8. XM_063266225.1XP_063122295.1  catenin beta-1 isoform X1

    9. XM_063266228.1XP_063122298.1  catenin beta-1 isoform X1

      Related
      ENSRNOP00000068620.2, ENSRNOT00000079085.3
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