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    Vrk3 VRK serine/threonine kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vrk3provided by RGD
    Official Full Name
    VRK serine/threonine kinase 3provided by RGD
    Primary source
    RGD:1549692
    See related
    EnsemblRapid:ENSRNOG00000026517 AllianceGenome:RGD:1549692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase binding activity and protein serine/threonine kinase activity. Predicted to be involved in DNA damage response; signal transduction; and skeletal muscle tissue development. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 139.3), Spleen (RPKM 120.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vrk3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104379903..104407278)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95243344..95270780)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100755622..100783008)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene IZUMO family member 2 Neighboring gene zinc finger protein 473 Neighboring gene activating transcription factor 5 Neighboring gene nucleoporin 62 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Kang TH, et al. Biochim Biophys Acta, 2008 Jan. PMID 18035061
    2. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249
    3. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Quiel A, et al. Biosens Bioelectron, 2012 Jun-Jul. PMID 22572157
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93929

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine/threonine-protein kinase VRK3
    Names
    serine/threonine-protein kinase VRK3
    vaccinia related kinase 3
    NP_001005561.2
    XP_063122703.1
    XP_063122707.1
    XP_063122713.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005561.2 → NP_001005561.2  inactive serine/threonine-protein kinase VRK3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F7F2H0, Q66HC2
      Related
      ENSRNOP00000076854.1, ENSRNOT00000108442.2
      Conserved Domains (4) summary
      COG0515
      Location:229 → 458
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam12773
      Location:14 → 38
      DZR; Double zinc ribbon
      pfam13240
      Location:13 → 35
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:143 → 445
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104379903..104407278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266643.1 → XP_063122713.1  inactive serine/threonine-protein kinase VRK3 isoform X2

      UniProtKB/TrEMBL
      Q66HC2

    2. XM_063266637.1 → XP_063122707.1  inactive serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      F7F2H0, Q66HC2

    3. XM_063266633.1 → XP_063122703.1  inactive serine/threonine-protein kinase VRK3 isoform X1

      UniProtKB/TrEMBL
      F7F2H0, Q66HC2
      Related
      ENSRNOP00000081238.2, ENSRNOT00000104717.2

    RNA

    1. XR_350316.5 RNA Sequence

    2. XR_350318.3 RNA Sequence

    3. XR_350317.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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