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    Trak1 trafficking kinesin protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trak1provided by RGD
    Official Full Name
    trafficking kinesin protein 1provided by RGD
    Primary source
    RGD:1307844
    See related
    EnsemblRapid:ENSRNOG00000019262 AllianceGenome:RGD:1307844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OIP106; RGD1307844
    Summary
    Enables TPR domain binding activity. Involved in axonal transport of mitochondrion; dendrite morphogenesis; and positive regulation of axonogenesis. Located in axonal growth cone; dendrite; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to human TRAK1 (trafficking kinesin protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 204.9), Muscle (RPKM 116.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trak1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (129861967..130016870)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (120984445..121139357)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (129946596..130106382)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene unc-51 like kinase 4 Neighboring gene uncharacterized LOC134480250 Neighboring gene uncharacterized LOC120094299 Neighboring gene uncharacterized LOC120094301 Neighboring gene uncharacterized LOC120094300 Neighboring gene uncharacterized LOC120094388 Neighboring gene cholecystokinin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy. Wu H, et al. Mol Neurobiol, 2021 Mar. PMID 33119838
    2. Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons. Loss O, et al. J Neurosci Res, 2015 Jul. PMID 25653102
    3. Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. Webber E, et al. J Mol Biol, 2008 Oct 10. PMID 18675823, Free PMC Article
    4. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. van Spronsen M, et al. Neuron, 2013 Feb 6. PMID 23395375
    5. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Gilbert SL, et al. Nat Genet, 2006 Feb. PMID 16380713

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
      Title: TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TPR domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonal transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trafficking kinesin-binding protein 1
    Names
    trafficking protein, kinesin binding 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134565.2 → NP_001128037.1  trafficking kinesin-binding protein 1

      See identical proteins and their annotated locations for NP_001128037.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZSR6, A0A8I6AI05, A6I434
      Related
      ENSRNOP00000026106.7, ENSRNOT00000026106.7
      Conserved Domains (4) summary
      pfam04849
      Location:49 → 352
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:421 → 580
      Milton; Kinesin associated protein
      cl12013
      Location:132 → 345
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl21478
      Location:263 → 355
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      129861967..130016870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081651.2 → XP_038937579.1  trafficking kinesin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A6I435
      Related
      ENSRNOP00000092949.1, ENSRNOT00000101633.2
      Conserved Domains (2) summary
      pfam04849
      Location:1 → 249
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:308 → 477
      Milton; Kinesin associated protein

    2. XM_039081652.2 → XP_038937580.1  trafficking kinesin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A6I435
      Conserved Domains (2) summary
      pfam04849
      Location:1 → 249
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:308 → 477
      Milton; Kinesin associated protein

    3. XM_039081653.2 → XP_038937581.1  trafficking kinesin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A6I435
      Conserved Domains (2) summary
      pfam04849
      Location:1 → 249
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:308 → 477
      Milton; Kinesin associated protein

    4. XM_039081645.2 → XP_038937573.1  trafficking kinesin-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI05
      Conserved Domains (2) summary
      pfam04849
      Location:49 → 352
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:411 → 580
      Milton; Kinesin associated protein

    5. XM_039081650.2 → XP_038937578.1  trafficking kinesin-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AI05
      Conserved Domains (2) summary
      pfam04849
      Location:49 → 352
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:411 → 580
      Milton; Kinesin associated protein

    6. XM_006244101.5 → XP_006244163.1  trafficking kinesin-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AI05
      Conserved Domains (4) summary
      pfam04849
      Location:49 → 352
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:421 → 580
      Milton; Kinesin associated protein
      cl12013
      Location:132 → 345
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl21478
      Location:263 → 355
      ATP-synt_B; ATP synthase B/B' CF(0)

    7. XM_039081656.2 → XP_038937584.1  trafficking kinesin-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5Y2D1
      Conserved Domains (2) summary
      pfam04849
      Location:49 → 352
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:411 → 580
      Milton; Kinesin associated protein

    8. XM_039081658.2 → XP_038937586.1  trafficking kinesin-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5Y2D1
      Related
      ENSRNOP00000078079.1, ENSRNOT00000112022.2
      Conserved Domains (2) summary
      pfam04849
      Location:49 → 352
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:411 → 580
      Milton; Kinesin associated protein

    9. XM_039081659.2 → XP_038937587.1  trafficking kinesin-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5Y2D1
      Conserved Domains (2) summary
      pfam04849
      Location:49 → 352
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:411 → 580
      Milton; Kinesin associated protein

    10. XM_039081654.2 → XP_038937582.1  trafficking kinesin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A6I435
      Conserved Domains (2) summary
      pfam04849
      Location:1 → 249
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:308 → 477
      Milton; Kinesin associated protein

    11. XM_039081655.2 → XP_038937583.1  trafficking kinesin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A6I435
      Conserved Domains (2) summary
      pfam04849
      Location:1 → 249
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:308 → 477
      Milton; Kinesin associated protein

    12. XM_063265659.1 → XP_063121729.1  trafficking kinesin-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A6I435

    13. XM_039081648.2 → XP_038937576.1  trafficking kinesin-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A6I435
      Conserved Domains (2) summary
      pfam04849
      Location:45 → 302
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:361 → 530
      Milton; Kinesin associated protein

    14. XM_006244102.5 → XP_006244164.1  trafficking kinesin-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A6I435
      Related
      ENSRNOP00000088532.2, ENSRNOT00000118223.2
      Conserved Domains (4) summary
      pfam12448
      Location:371 → 530
      Milton; Kinesin associated protein
      pfam14662
      Location:74 → 290
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl12013
      Location:82 → 295
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl21478
      Location:213 → 305
      ATP-synt_B; ATP synthase B/B' CF(0)

    15. XM_008766680.4 → XP_008764902.2  trafficking kinesin-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A6I435
      Conserved Domains (2) summary
      pfam04849
      Location:45 → 302
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:361 → 530
      Milton; Kinesin associated protein

    16. XM_039081646.2 → XP_038937574.1  trafficking kinesin-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A6I435
      Conserved Domains (2) summary
      pfam04849
      Location:85 → 342
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:401 → 570
      Milton; Kinesin associated protein

    17. XM_063265661.1 → XP_063121731.1  trafficking kinesin-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A6I435
      Related
      ENSRNOP00000099413.1, ENSRNOT00000168194.1

    18. XM_063265660.1 → XP_063121730.1  trafficking kinesin-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A6I435

    RNA

    1. XR_010053987.1 RNA Sequence

    2. XR_010053988.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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