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    Itpkc inositol-trisphosphate 3-kinase C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308451, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itpkcprovided by RGD
    Official Full Name
    inositol-trisphosphate 3-kinase Cprovided by RGD
    Primary source
    RGD:631336
    See related
    EnsemblRapid:ENSRNOG00000013945 AllianceGenome:RGD:631336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IP3K-C
    Summary
    Enables kinase activity. Predicted to be involved in cellular response to calcium ion; inositol phosphate biosynthetic process; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human ITPKC (inositol-trisphosphate 3-kinase C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 54.2), Kidney (RPKM 33.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Itpkc in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91628606..91650182, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82500957..82522533, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (84018857..84040433, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain containing Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene actin maturation protease Neighboring gene coenzyme Q8B Neighboring gene NUMB-like, endocytic adaptor protein Neighboring gene ribosomal protein L14, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables calmodulin binding  
    enables inositol hexakisphosphate kinase activity  
    enables inositol-1,4,5-trisphosphate 3-kinase activity  
    enables inositol-1,4,5-trisphosphate 3-kinase activity  
    enables inositol-1,4,5-trisphosphate 3-kinase activity  
    enables kinase activity PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nuclear speck  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    inositol-trisphosphate 3-kinase C
    Names
    IP3 3-kinase C
    IP3K C
    inositol 1,4,5-trisphosphate 3-kinase C
    insP 3-kinase C
    NP_835195.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178094.3NP_835195.1  inositol-trisphosphate 3-kinase C

      See identical proteins and their annotated locations for NP_835195.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ440782
      UniProtKB/Swiss-Prot
      Q80ZG2
      UniProtKB/TrEMBL
      A0A8L2UJ86, A6J9B8
      Related
      ENSRNOP00000084385.1, ENSRNOT00000100648.2
      Conserved Domains (1) summary
      pfam03770
      Location:462673
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      91628606..91650182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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