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    Trit1 tRNA isopentenyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trit1provided by RGD
    Official Full Name
    tRNA isopentenyltransferase 1provided by RGD
    Primary source
    RGD:1304781
    See related
    EnsemblRapid:ENSRNOG00000014274 AllianceGenome:RGD:1304781
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in mitochondrial tRNA modification. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 104.0), Adrenal (RPKM 97.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trit1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140578459..140623881)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135293472..135341522)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140711943..140756893)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909490 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene MYCL proto-oncogene, bHLH transcription factor Neighboring gene bone morphogenetic protein 8b Neighboring gene 3-oxoacid CoA transferase 2B Neighboring gene peptidylprolyl isomerase E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA. Yarham JW, et al. PLoS Genet, 2014 Jun. PMID 24901367, Free PMC Article
    2. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dimethylallyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dimethylallyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA dimethylallyltransferase
    Names
    tRNA dimethylallyltransferase, mitochondrial
    NP_001102146.1
    XP_006238866.1
    XP_038966235.1
    XP_038966237.1
    XP_063144055.1
    XP_063144056.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108676.1 → NP_001102146.1  tRNA dimethylallyltransferase

      See identical proteins and their annotated locations for NP_001102146.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS14, D4A175
      Related
      ENSRNOP00000019587.4, ENSRNOT00000019587.6
      Conserved Domains (3) summary
      PLN02748
      Location:25 → 440
      PLN02748; tRNA dimethylallyltransferase
      PRK00091
      Location:24 → 345
      miaA; tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed
      pfam12171
      Location:407 → 431
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      140578459..140623881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110307.2 → XP_038966235.1  tRNA dimethylallyltransferase isoform X1

      Conserved Domains (3) summary
      pfam01715
      Location:80 → 354
      IPPT; IPP transferase
      pfam12171
      Location:416 → 440
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl17190
      Location:17 → 55
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. XM_006238804.5 → XP_006238866.1  tRNA dimethylallyltransferase isoform X2

      Conserved Domains (2) summary
      PRK00091
      Location:24 → 333
      miaA; tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed
      pfam12171
      Location:395 → 419
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. XM_063287986.1 → XP_063144056.1  tRNA dimethylallyltransferase isoform X3

    4. XM_063287985.1 → XP_063144055.1  tRNA dimethylallyltransferase isoform X1

    5. XM_039110309.2 → XP_038966237.1  tRNA dimethylallyltransferase isoform X4

      Conserved Domains (2) summary
      pfam01715
      Location:7 → 106
      IPPT; IPP transferase
      pfam12171
      Location:168 → 192
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RNA

    1. XR_005504486.2 RNA Sequence

    2. XR_010066422.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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