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    Adpgk ADP-dependent glucokinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315722, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adpgkprovided by RGD
    Official Full Name
    ADP-dependent glucokinaseprovided by RGD
    Primary source
    RGD:1306103
    See related
    EnsemblRapid:ENSRNOG00000026178 AllianceGenome:RGD:1306103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306103
    Summary
    Predicted to enable ADP-specific glucokinase activity. Predicted to be involved in glucose metabolic process. Predicted to be active in endoplasmic reticulum. Orthologous to human ADPGK (ADP dependent glucokinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 134.3), Brain (RPKM 127.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Adpgk in Genome Data Viewer
    Location:
    8q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (68595194..68623179)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (59699400..59727352)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64088871..64116832)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479976 Neighboring gene ribosomal protein S2, pseudogene 27 Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene ribosomal protein L13, pseudogene 16 Neighboring gene ariadne RBR E3 ubiquitin protein ligase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP-specific glucokinase activity  
    enables ADP-specific glucokinase activity  
    Process Evidence Code Pubs
    involved_in glucose metabolic process  
    acts_upstream_of_or_within glucose metabolic process  
    involved_in glycolytic process  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  

    General protein information

    Preferred Names
    ADP-dependent glucokinase
    NP_001094193.1
    XP_006243232.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100723.1NP_001094193.1  ADP-dependent glucokinase precursor

      See identical proteins and their annotated locations for NP_001094193.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J519, Q5D001
      Related
      ENSRNOP00000013022.7, ENSRNOT00000013022.7
      Conserved Domains (1) summary
      cd01938
      Location:60492
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      68595194..68623179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243170.5XP_006243232.1  ADP-dependent glucokinase isoform X1

      UniProtKB/TrEMBL
      G3V784, Q5D001
      Conserved Domains (1) summary
      cd01938
      Location:60491
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
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