Ucn urocortin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ucnprovided by RGD
Official Full Name: urocortinprovided by RGD
Primary source: RGD:3929
See related: EnsemblRapid:ENSRNOG00000006090 AllianceGenome:RGD:3929
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables corticotropin-releasing hormone receptor 1 binding activity; corticotropin-releasing hormone receptor 2 binding activity; and histone deacetylase inhibitor activity. Involved in several processes, including negative regulation of cell size; positive regulation of macromolecule metabolic process; and regulation of hormone secretion. Located in axon; dendrite; and perikaryon. Used to study Parkinsonism and thromboangiitis obliterans. Biomarker of asthma; colitis; and thromboangiitis obliterans. Orthologous to human UCN (urocortin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 22.7), Heart (RPKM 19.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (30958086..30958916)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25238120..25238950)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26602144..26602974)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system.
Title: Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system.
Ucn induces activation of STAT3 through diverging signaling pathways.
Title: Urocortin Induces Phosphorylation of Distinct Residues of Signal Transducer and Activator of Transcription 3 (STAT3) via Different Signaling Pathways.
Polydatin significantly reduced the inflammatory mediators and restored the normal values of oxidative and nitrosative stress biomarkers. It also significantly reduced the expression of surfactant-D and UCN as compared to asthma control
Title: Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression.
Study found reduced miR-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced its levels.
Title: MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression.
Effects of early life stress and 5-HTT genotype at the molecular level could constitute early life stress x 5-HTT genotype interaction modulating the impact of stress on Edinger-Westphal-Ucn1 and dorsal raphe-5-HT neurons.
Title: Serotonin and urocortin 1 in the dorsal raphe and Edinger-Westphal nuclei after early life stress in serotonin transporter knockout rats.
urocortin may play a cytoprotective role in the germ cells in response to ischemia-reperfusion injury through the activation of major anti-apoptotic proteins, as well as by the mitogen-activated protein kinase signaling pathway activation.
Title: Characterization of urocortin as an anti-apoptotic protein in experimental ischemia-reperfusion model of the rat testis.
Results suggest that sex differences exist in the distribution of UCN-1 within brainstem autonomic areas, and circulating level of estrogen may play an important role with regards to the function of these UCN-1 neurons during stress responses
Title: Sex and estrogen affect the distribution of urocortin-1 immunoreactivity in brainstem autonomic nuclei of the rat.
UCN might contribute to regulate late midbrain dopaminergic neuron differentiation during ventral midbrain development.
Title: Epigenetic regulation contributes to urocortin-enhanced midbrain dopaminergic neuron differentiation.
UCN, CRHR1 and CRHR2 are expressed in the rat epididymis. It is suggested that CRH-related peptides might play multiple roles in the maturation and storage of spermatozoa.
Title: Expression of urocortin and its receptors in the rat epididymis.
Urocortin-1 expressing premotor neurons are located within the Edinger-Westphal nucleus.
Title: A subset of presympathetic-premotor neurons within the centrally projecting Edinger-Westphal nucleus expresses urocortin-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone receptor 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables corticotropin-releasing hormone receptor 2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase A activity	IDA Inferred from Direct Assay more info	PubMed
involved_in aerobic respiration	IDA Inferred from Direct Assay more info	PubMed
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in learning or memory	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell size	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of behavioral fear response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular permeability	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in response to auditory stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in response to immobilization stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pain	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in response to starvation	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in social behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in startle response	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: urocortin

Names: corticotensin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.