Abi2 abl-interactor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abi2provided by RGD
Official Full Name: abl-interactor 2provided by RGD
Primary source: RGD:628771
See related: EnsemblRapid:ENSRNOG00000017707 AllianceGenome:RGD:628771
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; lens fiber cell morphogenesis; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within several processes, including generation of neurons; learning or memory; and peptidyl-tyrosine phosphorylation. Predicted to be located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Predicted to be part of SCAR complex. Predicted to be active in several cellular components, including adherens junction; glutamatergic synapse; and postsynaptic actin cytoskeleton. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 483.5), Heart (RPKM 145.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (69321072..69490630)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (61827186..61905703)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (67234612..67284504)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138713 (e-PCR)
- UniSTS:220800

BE117293 (e-PCR)
- UniSTS:261771

RH138748 (e-PCR)
- UniSTS:220835

Abi2 (e-PCR), detects polymorphism
- UniSTS:532413

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in zonula adherens assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
is_active_in actin-based cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: abl interactor 2

Names: rCG22366-like; thyroid hormone responsive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393698.1 → NP_001380627.1 abl interactor 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6IPC7, F1LYA6

Related

ENSRNOP00000078426.2, ENSRNOT00000113763.2

Conserved Domains (2) summary

cd11972
Location:413 → 473

SH3_Abi2; Src homology 3 domain of Abl Interactor 2

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR
NM_173143.2 → NP_775166.2 abl interactor 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

F1LYA6

Conserved Domains (1) summary

cd11972
Location:384 → 444

SH3_Abi2; Src homology 3 domain of Abl Interactor 2