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    Fam20c FAM20C, golgi associated secretory pathway kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam20cprovided by RGD
    Official Full Name
    FAM20C, golgi associated secretory pathway kinaseprovided by RGD
    Primary source
    RGD:1311980
    See related
    EnsemblRapid:ENSRNOG00000001314 AllianceGenome:RGD:1311980
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311980
    Summary
    Enables protein serine/threonine kinase activity. Involved in odontoblast differentiation and protein phosphorylation. Predicted to be located in Golgi membrane; extracellular space; and nucleoplasm. Predicted to colocalize with Golgi apparatus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta. Orthologous to human FAM20C (FAM20C golgi associated secretory pathway kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 367.0), Brain (RPKM 91.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam20c in Genome Data Viewer
    Location:
    12q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20940654..20999072, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15826864..15885423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17913771..17972733, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S27-like Neighboring gene forkhead box L3 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B, pseudogene Neighboring gene zinc finger protein 846

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Polyhalogenobenzimidazoles: synthesis and their inhibitory activity against casein kinases. Andrzejewska M, et al. Bioorg Med Chem, 2003 Sep 1. PMID 12927861
    2. Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization. Oya K, et al. Histochem Cell Biol, 2017 Mar. PMID 27614627
    3. Variability of systemic and oro-dental phenotype in two families with non-lethal Raine syndrome with FAM20C mutations. Acevedo AC, et al. BMC Med Genet, 2015 Feb 21. PMID 25928877, Free PMC Article
    4. Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation. Hao J, et al. J Biol Chem, 2007 May 25. PMID 17369251
    5. Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development. Simpson MA, et al. Am J Hum Genet, 2007 Nov. PMID 17924334, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OPN, besides being overexpressed in hepatic stellate cells, is substantially phosphorylated by family with sequence similarity 20, member C (Fam20C), formerly known as Golgi casein kinase (G-CK), which is exclusively resident in the Golgi apparatus
      Title: Fam20C-mediated phosphorylation of osteopontin is critical for its secretion but dispensable for its action as a cytokine in the activation of hepatic stellate cells in liver fibrogenesis.
    2. Phosphorylated Fam20C in the pericanalicular matrix may play an important role in bone mineralization by recruiting calcium ions.
      Title: Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biomineral tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dentinogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in enamel mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within enamel mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in odontoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within odontoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoclast maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of phosphorus metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    extracellular serine/threonine protein kinase FAM20C
    Names
    dentin matrix protein 4
    family with sequence similarity 20, member C
    NP_001012238.1
    XP_038945323.1
    XP_038945324.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012238.1 → NP_001012238.1  extracellular serine/threonine protein kinase FAM20C

      See identical proteins and their annotated locations for NP_001012238.1

      Status: PROVISIONAL

      Source sequence(s)
      BK001522
      UniProtKB/TrEMBL
      A6K1Z1, B1WBN7
      Related
      ENSRNOP00000001783.4, ENSRNOT00000001783.9
      Conserved Domains (2) summary
      cd10471
      Location:349 → 560
      FAM20C_C; C-terminal putative kinase domain of FAM20C (also known as Dentin Matrix Protein 4, DMP4)
      PHA03307
      Location:35 → 154
      PHA03307; transcriptional regulator ICP4; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      20940654..20999072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089395.2 → XP_038945323.1  extracellular serine/threonine protein kinase FAM20C isoform X1

      Conserved Domains (1) summary
      cl05973
      Location:349 → 450
      FAM20_C_like; C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins

    2. XM_039089396.2 → XP_038945324.1  extracellular serine/threonine protein kinase FAM20C isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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