Dnah7 dynein, axonemal, heavy chain 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnah7provided by RGD
Official Full Name: dynein, axonemal, heavy chain 7provided by RGD
Primary source: RGD:621798
See related: EnsemblRapid:ENSRNOG00000060984 AllianceGenome:RGD:621798
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: axo b
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement and inner dynein arm assembly. Predicted to be located in cilium and cytosol. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 64.9), Lung (RPKM 39.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9q31

Exon count:: 66

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (62454838..62760504, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (54960235..55266529, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (60070087..60330121, complement) , (59564253..59595347, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D9Rat22 (e-PCR)
- UniSTS:119162

DNAH7__4760 (e-PCR)
- UniSTS:463254

RH127346 (e-PCR)
- UniSTS:210656

RH140829 (e-PCR)
- UniSTS:210656

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cilium movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner dynein arm assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
part_of inner dynein arm	IBA Inferred from Biological aspect of Ancestor more info
part_of inner dynein arm	IEA Inferred from Electronic Annotation more info
part_of inner dynein arm	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein axonemal heavy chain 7

Names: axonemal beta dynein heavy chain 7; axonemal dynein heavy chain b; ciliary dynein heavy chain 7; dynein heavy chain 7, axonemal; dynein, axonemal, heavy polypeptide 7; dynein-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419550.1 → NP_001406479.1 dynein axonemal heavy chain 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6A3H4, A0A8I6A4S9

Related

ENSRNOP00000085933.1, ENSRNOT00000106935.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

62454838..62760504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084571.2 → XP_038940499.1 dynein axonemal heavy chain 7 isoform X2

UniProtKB/TrEMBL

A0A8I6A4S9

Conserved Domains (6) summary

COG5245
Location:933 → 3640

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:731 → 1136

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1264 → 1590

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12780
Location:2285 → 2547

AAA_8; P-loop containing dynein motor region D4

pfam12781
Location:2937 → 3153

AAA_9; ATP-binding dynein motor region D5

pfam18199
Location:3694 → 3994

Dynein_C; Dynein heavy chain C-terminal domain
XM_039084570.2 → XP_038940498.1 dynein axonemal heavy chain 7 isoform X1

UniProtKB/TrEMBL

A0A0G2JYD0, A0A8I6A4S9

Related

ENSRNOP00000070606.2, ENSRNOT00000092162.3

Conserved Domains (6) summary

COG5245
Location:937 → 3644

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:735 → 1140

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1268 → 1594

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12780
Location:2289 → 2551

AAA_8; P-loop containing dynein motor region D4

pfam12781
Location:2941 → 3157

AAA_9; ATP-binding dynein motor region D5

pfam18199
Location:3698 → 3998

Dynein_C; Dynein heavy chain C-terminal domain
XM_039084573.2 → XP_038940501.1 dynein axonemal heavy chain 7 isoform X3

Conserved Domains (6) summary

pfam17857
Location:2151 → 2210

AAA_lid_1; AAA+ lid domain

pfam08393
Location:756 → 1161

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1289 → 1615

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12775
Location:1937 → 2117

AAA_7; P-loop containing dynein motor region D3

pfam17852
Location:1781 → 1928

Dynein_AAA_lid; Dynein heavy chain AAA lid domain

cl38936
Location:1603 → 1746

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases