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    Tspo translocator protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24230, updated on 27-Dec-2024

    Summary

    Official Symbol
    Tspoprovided by RGD
    Official Full Name
    translocator proteinprovided by RGD
    Primary source
    RGD:2228
    See related
    EnsemblRapid:ENSRNOG00000010549 AllianceGenome:RGD:2228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MBR; Bzrp; Ptbzr; PTBZR02; RATPTBZR02
    Summary
    Enables androgen binding activity and benzodiazepine receptor activity. Involved in several processes, including positive regulation of programmed cell death; regulation of biosynthetic process; and regulation of glial cell proliferation. Located in mitochondrial outer membrane. Used to study cholesterol ester storage disease. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 1092.6), Lung (RPKM 365.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Tspo in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116600214..116610461)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114720188..114730450)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124460358..124470610)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479952 Neighboring gene uncharacterized LOC134479950 Neighboring gene malonyl-CoA-acyl carrier protein transacylase Neighboring gene tubulin tyrosine ligase like 12 Neighboring gene uncharacterized LOC134479949 Neighboring gene signal peptide, CUB domain and EGF like domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in adrenal gland development PubMed 
    involved_in behavioral response to pain PubMed 
    involved_in cellular hypotonic response PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to zinc ion PubMed 
    involved_in chloride transport PubMed 
    involved_in cholesterol homeostasis PubMed 
    involved_in contact inhibition PubMed 
    involved_in establishment of protein localization to mitochondrion  
    involved_in glial cell migration PubMed 
    involved_in lipid transport  
    involved_in maintenance of protein location in mitochondrion  
    involved_in monoatomic ion transport PubMed 
    involved_in negative regulation of ATP metabolic process  
    involved_in negative regulation of corticosterone secretion PubMed 
    involved_in negative regulation of glial cell proliferation PubMed 
    involved_in negative regulation of mitophagy  
    involved_in negative regulation of nitric oxide biosynthetic process PubMed 
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of tumor necrosis factor production PubMed 
    involved_in peripheral nervous system axon regeneration PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of calcium ion transport PubMed 
    involved_in positive regulation of glial cell proliferation PubMed 
    involved_in positive regulation of mitochondrial depolarization PubMed 
    involved_in positive regulation of programmed necrotic cell death PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in regulation of steroid biosynthetic process PubMed 
    involved_in response to acetylcholine PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to manganese ion PubMed 
    involved_in response to pain PubMed 
    involved_in response to progesterone PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to vitamin B1 PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in steroid biosynthetic process PubMed 
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    is_active_in membrane  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    translocator protein
    Names
    Benzodiazepin receptor (peripheral)
    PBR
    PKBS
    benzodiazepine receptor, peripheral
    mitochondrial benzodiazepine receptor
    peripheral-type benzodiazepine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012515.2NP_036647.1  translocator protein

      See identical proteins and their annotated locations for NP_036647.1

      Status: VALIDATED

      Source sequence(s)
      BQ194961, FM047408, J05122
      UniProtKB/Swiss-Prot
      P16257
      UniProtKB/TrEMBL
      A6HTA0
      Related
      ENSRNOP00000014089.1, ENSRNOT00000014089.6
      Conserved Domains (1) summary
      pfam03073
      Location:12155
      TspO_MBR; TspO/MBR family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116600214..116610461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078393.2XP_038934321.1  translocator protein isoform X1

      UniProtKB/Swiss-Prot
      P16257
      UniProtKB/TrEMBL
      A6HTA0
      Conserved Domains (1) summary
      pfam03073
      Location:12155
      TspO_MBR; TspO/MBR family
    2. XM_039078394.2XP_038934322.1  translocator protein isoform X1

      UniProtKB/Swiss-Prot
      P16257
      UniProtKB/TrEMBL
      A6HTA0
      Conserved Domains (1) summary
      pfam03073
      Location:12155
      TspO_MBR; TspO/MBR family
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