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    Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25086, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp2e1provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily e, polypeptide 1provided by RGD
    Primary source
    RGD:2475
    See related
    EnsemblRapid:ENSRNOG00000012458 AllianceGenome:RGD:2475
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp2e
    Summary
    Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to 3-methylcholanthrene; response to ethanol; and response to ozone. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study alcohol dependence and drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; liver disease (multiple); middle cerebral artery infarction; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acoustic neuroma; gastrointestinal system cancer (multiple); high grade glioma; liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 11351.2) and Kidney (RPKM 1709.8) See more
    Orthologs
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    Genomic context

    See Cyp2e1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205269967..205280365)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (195840330..195850728)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213511892..213522195)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 13 subfamily A member 26 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene synaptonemal complex central element protein 1 Neighboring gene vacuole membrane protein 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-nitrophenol 2-monooxygenase activity  
    enables 4-nitrophenol 2-monooxygenase activity  
    enables Hsp70 protein binding PubMed 
    enables Hsp70 protein binding  
    enables Hsp90 protein binding PubMed 
    enables Hsp90 protein binding  
    enables arachidonate epoxygenase activity  
    enables aromatase activity  
    enables enzyme binding  
    enables enzyme binding  
    enables heme binding  
    enables heme binding  
    enables heme binding  
    enables heme binding  
    enables iron ion binding  
    enables long-chain fatty acid omega-1 hydroxylase activity  
    enables long-chain fatty acid omega-1 hydroxylase activity  
    enables monooxygenase activity  
    enables monooxygenase activity PubMed 
    enables oxidoreductase activity  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  
    Process Evidence Code Pubs
    involved_in 4-nitrophenol metabolic process  
    involved_in 4-nitrophenol metabolic process  
    involved_in epoxygenase P450 pathway  
    involved_in fatty acid metabolic process  
    involved_in lipid hydroxylation  
    involved_in lipid hydroxylation  
    involved_in long-chain fatty acid metabolic process  
    involved_in long-chain fatty acid metabolic process  
    involved_in monoterpenoid metabolic process  
    involved_in monoterpenoid metabolic process  
    involved_in response to 3-methylcholanthrene PubMed 
    involved_in response to bacterium  
    acts_upstream_of_or_within response to bacterium  
    involved_in response to ethanol PubMed 
    involved_in response to ozone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in steroid metabolic process  
    involved_in steroid metabolic process  
    involved_in triglyceride metabolic process PubMed 
    involved_in xenobiotic metabolic process  
    involved_in xenobiotic metabolic process  
    involved_in xenobiotic metabolic process PubMed 
    involved_in xenobiotic metabolic process  
    involved_in xenobiotic metabolic process PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane PubMed 
    is_active_in cytoplasm  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    is_active_in intracellular membrane-bounded organelle  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  

    General protein information

    Preferred Names
    cytochrome P450 2E1
    Names
    4-nitrophenol 2-hydroxylase
    CYPIIE1
    P450-J
    P450RLM6
    cytochrome P450 subfamily 2e1 (ethanol-inducible)
    cytochrome P450, subfamily 2E, polypeptide 1
    cytochrome P450-J
    cytochrome P450RLM6
    NP_113731.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031543.2NP_113731.2  cytochrome P450 2E1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P05182
      UniProtKB/TrEMBL
      A0A8L2Q8J4, A6HXJ0
      Related
      ENSRNOP00000016883.5, ENSRNOT00000016883.8
      Conserved Domains (1) summary
      cd20665
      Location:64487
      CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205269967..205280365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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