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    Mug1 murinoglobulin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497794, updated on 9-Dec-2024

    Summary

    Symbol
    Mug1provided by RGD
    Full Name
    murinoglobulin 1provided by RGD
    Primary source
    RGD:621366
    See related
    EnsemblRapid:ENSRNOG00000091232 AllianceGenome:RGD:621366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A1i3
    Summary
    Predicted to enable endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in acute-phase response and negative regulation of peptidase activity. Predicted to act upstream of or within embryo implantation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 14140.2) See more
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    Genomic context

    See Mug1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156748351..156802132)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (155076270..155130051)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154676382..154729288)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene murinoglobulin 1 like 1 Neighboring gene thymosin beta-10 pseudogene Neighboring gene salvador family WW domain containing protein 1, pseudogene 1 Neighboring gene uncharacterized LOC108350756 Neighboring gene murinoglobulin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity  
    enables endopeptidase inhibitor activity  
    enables peptidase inhibitor activity PubMed 
    enables protease binding  
    enables serine-type endopeptidase inhibitor activity  
    Component Evidence Code Pubs
    located_in extracellular region  
    located_in extracellular space  

    General protein information

    Preferred Names
    murinoglobulin-1
    Names
    Murinoglobulin 1 homolog
    alpha x protein
    alpha-1-inhibitor III
    alpha-X protein
    murinoglobulin-1-like
    plasma proteinase inhibitor alpha-1-inhibitor III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023103.1NP_075591.1  murinoglobulin-1 precursor

      See identical proteins and their annotated locations for NP_075591.1

      Status: PROVISIONAL

      Source sequence(s)
      X52984
      UniProtKB/Swiss-Prot
      Q03310, Q03626, Q63018, Q63020, Q63023, Q78DZ4, Q9JMK7
      UniProtKB/TrEMBL
      D4A6E3
      Related
      ENSRNOP00000019969.5, ENSRNOT00000019969.8
      Conserved Domains (6) summary
      cd02897
      Location:9711277
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:751841
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129221
      A2M_N; MG2 domain
      pfam07677
      Location:13891476
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10241279
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      156748351..156802132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237282.5XP_006237344.1  murinoglobulin-1 isoform X1

      UniProtKB/TrEMBL
      D4A6E3
      Related
      ENSRNOP00000069175.2, ENSRNOT00000079192.3
      Conserved Domains (6) summary
      cd02897
      Location:9711277
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:751841
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129221
      A2M_N; MG2 domain
      pfam07677
      Location:13891476
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10241279
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
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