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    Kcnd3 potassium voltage-gated channel subfamily D member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65195, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnd3provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily D member 3provided by RGD
    Primary source
    RGD:68394
    See related
    EnsemblRapid:ENSRNOG00000014686 AllianceGenome:RGD:68394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv4.3
    Summary
    Enables A-type (transient outward) potassium channel activity. Involved in cellular response to BMP stimulus; potassium ion export across plasma membrane; and potassium ion import across plasma membrane. Located in several cellular components, including caveola; neuronal cell body; and perinuclear endoplasmic reticulum. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 79.7), Uterus (RPKM 58.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Kcnd3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (195626316..195843690)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (192937950..193155345)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207923775..208140727)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100906 Neighboring gene uncharacterized LOC103691662 Neighboring gene uncharacterized LOC134485946 Neighboring gene DEAD-box helicase 20 Neighboring gene inka box actin regulator 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity PubMed 
    enables A-type (transient outward) potassium channel activity  
    enables A-type (transient outward) potassium channel activity PubMed 
    contributes_to A-type (transient outward) potassium channel activity  
    enables A-type (transient outward) potassium channel activity  
    enables metal ion binding  
    enables monoatomic ion channel activity PubMed 
    enables potassium channel activity PubMed 
    enables protein binding PubMed 
    enables voltage-gated potassium channel activity PubMed 
    enables voltage-gated potassium channel activity  
    enables voltage-gated potassium channel activity PubMed 
    enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  
    contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  
    Process Evidence Code Pubs
    involved_in action potential  
    involved_in cellular response to BMP stimulus PubMed 
    involved_in membrane repolarization  
    involved_in membrane repolarization during ventricular cardiac muscle cell action potential  
    involved_in potassium ion export across plasma membrane  
    involved_in potassium ion export across plasma membrane PubMed 
    involved_in potassium ion export across plasma membrane  
    involved_in potassium ion export across plasma membrane  
    involved_in potassium ion import across plasma membrane PubMed 
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transport PubMed 
    involved_in potassium ion transport  
    involved_in potassium ion transport PubMed 
    involved_in protein homooligomerization  
    involved_in protein tetramerization  
    involved_in protein tetramerization  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in ventricular cardiac muscle cell membrane repolarization  
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in GABA-ergic synapse  
    is_active_in GABA-ergic synapse  
    part_of Kv4.3-KChIP1 channel complex  
    part_of Kv4.3-KChIP1 channel complex  
    located_in caveola PubMed 
    located_in dendrite PubMed 
    is_active_in dendritic spine  
    located_in membrane  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    located_in perinuclear endoplasmic reticulum PubMed 
    located_in plasma membrane  
    is_active_in postsynaptic membrane  
    located_in postsynaptic specialization membrane  
    is_active_in postsynaptic specialization membrane  
    located_in sarcolemma  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    A-type voltage-gated potassium channel KCND3
    Names
    potassium channel, voltage-gated Shal-related subfamily D, member 3
    potassium voltage gated channel, Shal-related family, member 3
    potassium voltage-gated channel, Shal-related subfamily, member 3
    voltage-gated potassium channel subunit Kv4.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270962.1NP_001257891.1  A-type voltage-gated potassium channel KCND3 isoform 1

      See identical proteins and their annotated locations for NP_001257891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as Kv4.3L and Kv4.3c) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08723, P70622, Q62897, Q63286, Q99P42
      UniProtKB/TrEMBL
      A0A0G2JSN5
      Related
      ENSRNOP00000019997.4, ENSRNOT00000019997.8
      Conserved Domains (6) summary
      smart00225
      Location:42139
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217412
      Ion_trans; Ion transport protein
      pfam02214
      Location:42131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:328408
      Ion_trans_2; Ion channel
      pfam11601
      Location:328
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:442563
      DUF3399; Domain of unknown function (DUF3399)
    2. NM_001270963.1NP_001257892.1  A-type voltage-gated potassium channel KCND3 isoform 2

      See identical proteins and their annotated locations for NP_001257892.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as Kv4.3M and Kv4.3a) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08723, P70622, Q62897, Q63286, Q99P42
      UniProtKB/TrEMBL
      A0A0G2JSW5
      Related
      ENSRNOP00000049111.2, ENSRNOT00000051835.6
      Conserved Domains (6) summary
      smart00225
      Location:42139
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217412
      Ion_trans; Ion transport protein
      pfam02214
      Location:42131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:328408
      Ion_trans_2; Ion channel
      pfam11601
      Location:328
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:442544
      DUF3399; Domain of unknown function (DUF3399)
    3. NM_031739.3NP_113927.2  A-type voltage-gated potassium channel KCND3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as Kv4.3S and Kv4.3b) lacks an in-frame exon in the 3' coding region, and lacks a segment in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08723, P70622, Q62897, Q63286, Q99P42
      Conserved Domains (6) summary
      smart00225
      Location:42139
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217412
      Ion_trans; Ion transport protein
      pfam02214
      Location:42131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:328408
      Ion_trans_2; Ion channel
      pfam11601
      Location:328
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:442544
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      195626316..195843690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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