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    Hs6st1 heparan sulfate 6-O-sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs6st1provided by RGD
    Official Full Name
    heparan sulfate 6-O-sulfotransferase 1provided by RGD
    Primary source
    RGD:1309218
    See related
    EnsemblRapid:ENSRNOG00000014516 AllianceGenome:RGD:1309218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and neuron development. Predicted to act upstream of or within blood vessel development; heparan sulfate proteoglycan biosynthetic process; and lung alveolus development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 192.8), Lung (RPKM 159.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hs6st1 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (45779402..45818583)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38283502..38322684)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (42620006..42659184)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094664 Neighboring gene uncharacterized LOC120094665 Neighboring gene Histone deacetylase 1, pseudogene 10 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 1 Neighboring gene uncharacterized LOC100909803

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism. Tornberg J, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21700882, Free PMC Article
    2. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. Habuchi H, et al. J Biol Chem, 2000 Jan 28. PMID 10644753
    3. Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. Habuchi H, et al. J Biol Chem, 2007 May 25. PMID 17405882
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparan sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 6-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan-sulfate 6-O-sulfotransferase 1
    NP_001101680.1
    XP_038939488.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108210.1 → NP_001101680.1  heparan-sulfate 6-O-sulfotransferase 1

      See identical proteins and their annotated locations for NP_001101680.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A6INC0
      Related
      ENSRNOP00000019966.6, ENSRNOT00000019966.8
      Conserved Domains (1) summary
      pfam03567
      Location:3 → 268
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      45779402..45818583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083560.2 → XP_038939488.1  heparan-sulfate 6-O-sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y4T0
      Related
      ENSRNOP00000076596.1, ENSRNOT00000119852.2
      Conserved Domains (1) summary
      cl22970
      Location:65 → 247
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version

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