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    Actc1 actin, alpha, cardiac muscle 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29275, updated on 9-Dec-2024

    Summary

    Official Symbol
    Actc1provided by RGD
    Official Full Name
    actin, alpha, cardiac muscle 1provided by RGD
    Primary source
    RGD:2026
    See related
    EnsemblRapid:ENSRNOG00000008536 AllianceGenome:RGD:2026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; microfilament motor activity; and myosin binding activity. Involved in cardiac muscle contraction; response to ethanol; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including I band; filopodium; and lamellipodium. Predicted to be part of protein-containing complex. Predicted to be active in actin filament; glutamatergic synapse; and sarcomere. Biomarker of hypertension. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 34035.4) See more
    Orthologs
    NEW
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    Genomic context

    See Actc1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (121266291..121271827, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (100811987..100817523, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (105507403..105512939, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 11A Neighboring gene uncharacterized LOC103691860 Neighboring gene uncharacterized LOC120101628 Neighboring gene gap junction protein, delta 2 Neighboring gene aquarius intron-binding spliceosomal factor Neighboring gene zinc finger protein 770

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC156490

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables hydrolase activity  
    enables microfilament motor activity  
    enables myosin binding  
    enables myosin binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in actin filament-based movement  
    acts_upstream_of_or_within actin-mediated cell contraction  
    involved_in actin-myosin filament sliding  
    involved_in actin-myosin filament sliding  
    acts_upstream_of_or_within actomyosin structure organization  
    involved_in cardiac muscle contraction PubMed 
    acts_upstream_of_or_within cardiac muscle tissue morphogenesis  
    acts_upstream_of_or_within cardiac myofibril assembly  
    involved_in glomerular mesangial cell development  
    involved_in heart contraction  
    involved_in heart contraction  
    involved_in mesenchyme migration  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    involved_in positive regulation of gene expression  
    involved_in regulation of blood pressure  
    involved_in response to ethanol PubMed 
    involved_in response to virus  
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within skeletal muscle thin filament assembly  
    involved_in vascular associated smooth muscle contraction  
    Component Evidence Code Pubs
    located_in I band  
    is_active_in actin cytoskeleton  
    located_in actin cytoskeleton  
    is_active_in actin filament  
    located_in actin filament  
    located_in cell body  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in filopodium  
    is_active_in glutamatergic synapse  
    located_in lamellipodium  
    located_in motile cilium  
    part_of protein-containing complex  
    is_active_in sarcomere  
    located_in sarcomere  
    located_in smooth muscle contractile fiber  
    is_active_in synapse  

    General protein information

    Preferred Names
    actin, alpha cardiac muscle 1
    Names
    actin, alpha, cardiac 1
    alpha-actin cardiac
    alpha-cardiac actin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019183.1NP_062056.1  actin, alpha cardiac muscle 1

      See identical proteins and their annotated locations for NP_062056.1

      Status: VALIDATED

      Source sequence(s)
      AI603593, AI706373, CF109672, CK356511
      UniProtKB/Swiss-Prot
      A0JPJ4, P68035
      UniProtKB/TrEMBL
      A0A0G2K4M6, A0A8I5ZVP6, A6HP76
      Related
      ENSRNOP00000011773.3, ENSRNOT00000011773.6
      Conserved Domains (1) summary
      PTZ00281
      Location:4377
      PTZ00281; actin; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      121266291..121271827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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