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    Ddx3x DEAD-box helicase 3, X-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317335, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddx3xprovided by RGD
    Official Full Name
    DEAD-box helicase 3, X-linkedprovided by RGD
    Primary source
    RGD:1564771
    See related
    EnsemblRapid:ENSRNOG00000023383 AllianceGenome:RGD:1564771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including helicase activity; nucleic acid binding activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within with a negative effect on primary miRNA processing. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 1032.7), Kidney (RPKM 995.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ddx3x in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (12152346..12165983, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (9479532..9493169, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (10400363..10414010, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099244 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 81 Neighboring gene large ribosomal subunit protein eL21 Neighboring gene uncharacterized LOC102547042

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables CTPase activity  
    enables DNA binding  
    enables DNA helicase activity  
    enables GTPase activity  
    enables RNA binding  
    enables RNA helicase activity  
    enables RNA helicase activity  
    enables RNA stem-loop binding  
    enables RNA strand annealing activity  
    enables eukaryotic initiation factor 4E binding  
    enables gamma-tubulin binding  
    enables mRNA 5'-UTR binding  
    enables mRNA binding  
    enables mRNA binding  
    enables poly(A) binding  
    enables primary miRNA binding  
    enables protein serine/threonine kinase activator activity  
    enables ribonucleoside triphosphate phosphatase activity  
    enables ribosomal small subunit binding  
    enables signaling adaptor activity  
    enables translation initiation factor binding  
    Items 1 - 25 of 54
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in RNA secondary structure unwinding  
    involved_in Wnt signaling pathway  
    involved_in cell differentiation  
    involved_in cellular response to arsenic-containing substance  
    involved_in cellular response to osmotic stress  
    involved_in cellular response to virus  
    involved_in chromosome segregation  
    involved_in cytosolic ribosome assembly  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in gamete generation  
    involved_in innate immune response  
    involved_in intracellular signal transduction  
    involved_in intrinsic apoptotic signaling pathway  
    involved_in lipid homeostasis  
    involved_in negative regulation by host of viral genome replication  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in negative regulation of translation  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of mitochondrial translation  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of protein K63-linked ubiquitination  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein autophosphorylation  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of toll-like receptor 7 signaling pathway  
    involved_in positive regulation of toll-like receptor 8 signaling pathway  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of translation  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress  
    involved_in positive regulation of translational initiation  
    involved_in positive regulation of type I interferon production  
    involved_in positive regulation of viral genome replication  
    acts_upstream_of_or_within_negative_effect primary miRNA processing  
    involved_in protein localization to cytoplasmic stress granule  
    involved_in response to virus  
    involved_in stress granule assembly  
    involved_in translational initiation  
    Items 1 - 25 of 54
    Component Evidence Code Pubs
    part_of NLRP3 inflammasome complex  
    is_active_in P granule  
    located_in cell leading edge  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule  
    is_active_in cytosol  
    located_in cytosol  
    part_of cytosolic small ribosomal subunit  
    part_of eukaryotic translation initiation factor 3 complex  
    is_active_in glutamatergic synapse PubMed 
    is_active_in mitochondrion  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    is_active_in postsynaptic density PubMed 

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX3X
    Names
    DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
    NP_001385680.1
    NP_001385681.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398751.1NP_001385680.1  ATP-dependent RNA helicase DDX3X isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4ADE8, W8BZ34
      Related
      ENSRNOP00000090648.1, ENSRNOT00000112352.2
      Conserved Domains (2) summary
      PTZ00110
      Location:56579
      PTZ00110; helicase; Provisional
      cd18051
      Location:159409
      DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3
    2. NM_001398752.1NP_001385681.1  ATP-dependent RNA helicase DDX3X isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      W8BZ34
      Related
      ENSRNOP00000029702.7, ENSRNOT00000039551.8
      Conserved Domains (2) summary
      PTZ00110
      Location:57580
      PTZ00110; helicase; Provisional
      cd18051
      Location:160410
      DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      12152346..12165983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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