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    Lcp2 lymphocyte cytosolic protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 155918, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lcp2provided by RGD
    Official Full Name
    lymphocyte cytosolic protein 2provided by RGD
    Primary source
    RGD:619743
    See related
    EnsemblRapid:ENSRNOG00000005620 AllianceGenome:RGD:619743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slp76
    Summary
    Predicted to be involved in cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of protein kinase activity. Predicted to act upstream of or within mast cell activation. Predicted to be located in cell-cell junction; cytosol; and plasma membrane raft. Predicted to be part of TCR signalosome. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 212.4), Spleen (RPKM 146.1) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Lcp2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (19146846..19193750)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18642600..18689562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18996523..19043289)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene uncharacterized LOC120095245 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 1 Neighboring gene uncharacterized LOC134480773 Neighboring gene similar to human chromosome 5 open reading frame 58 Neighboring gene forkhead box I1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of TCR signalosome  
    located_in cell-cell junction  
    located_in cytosol  
    located_in plasma membrane raft  

    General protein information

    Preferred Names
    lymphocyte cytosolic protein 2
    Names
    lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130421.2NP_569105.1  lymphocyte cytosolic protein 2

      See identical proteins and their annotated locations for NP_569105.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100066
      UniProtKB/TrEMBL
      A0A8J8YIH6, F1LNJ9, Q920L0
      Related
      ENSRNOP00000098753.1, ENSRNOT00000168848.1
      Conserved Domains (3) summary
      cd09522
      Location:1078
      SAM_SLP76; SAM domain of SLP76 subfamily
      smart00454
      Location:1270
      SAM; Sterile alpha motif
      cd09929
      Location:402523
      SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      19146846..19193750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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