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    Rap1b RAP1B, member of RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171337, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rap1bprovided by RGD
    Official Full Name
    RAP1B, member of RAS oncogene familyprovided by RGD
    Primary source
    RGD:620577
    See related
    EnsemblRapid:ENSRNOG00000007048 AllianceGenome:RGD:620577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein activity; GDP binding activity; and GTP binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to xenobiotic stimulus; and response to carbohydrate. Predicted to be located in cell-cell junction; cytosol; and lipid droplet. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 789.4), Lung (RPKM 486.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rap1b in Genome Data Viewer
    Location:
    7q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (55308922..55342217, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (53423039..53456349, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60850406..60878226, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351461 Neighboring gene solute carrier family 35, member E3 Neighboring gene nucleoporin 107 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13, pseudogene 3 Neighboring gene SWI5-dependent homologous recombination repair protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120093606

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93206

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables GDP binding  
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables protein-containing complex binding  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction  
    involved_in Rap protein signal transduction  
    involved_in Rap protein signal transduction  
    involved_in Rap protein signal transduction  
    acts_upstream_of calcium-ion regulated exocytosis  
    acts_upstream_of_or_within cell population proliferation  
    involved_in cellular response to cAMP  
    involved_in cellular response to cAMP  
    involved_in cellular response to cAMP  
    involved_in cellular response to gonadotropin-releasing hormone PubMed 
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in establishment of endothelial barrier  
    involved_in establishment of endothelial barrier  
    acts_upstream_of establishment of localization in cell  
    NOT involved_in microvillus assembly  
    involved_in modification of postsynaptic structure  
    acts_upstream_of_or_within negative regulation of calcium ion-dependent exocytosis  
    involved_in negative regulation of synaptic vesicle exocytosis  
    acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of integrin activation  
    involved_in regulation of cell junction assembly  
    involved_in regulation of cell junction assembly  
    involved_in regulation of establishment of cell polarity  
    involved_in regulation of establishment of cell polarity  
    involved_in response to carbohydrate PubMed 
    acts_upstream_of_or_within small GTPase-mediated signal transduction  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in cell-cell junction  
    located_in cell-cell junction  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse  
    located_in lipid droplet  
    NOT located_in membrane raft  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ras-related protein Rap-1b
    Names
    GTP-binding protein smg p21B
    RAS related protein 1b
    NP_001399529.1
    NP_599173.2
    XP_038934285.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412600.1NP_001399529.1  ras-related protein Rap-1b precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q62636, Q6J167
      UniProtKB/TrEMBL
      A0A8L2UI57, A6IGU3
      Related
      ENSRNOP00000078778.1, ENSRNOT00000113270.2
    2. NM_134346.4NP_599173.2  ras-related protein Rap-1b precursor

      See identical proteins and their annotated locations for NP_599173.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q62636, Q6J167
      UniProtKB/TrEMBL
      A0A8L2UI57, A6IGU3
      Conserved Domains (1) summary
      cd04175
      Location:3167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      55308922..55342217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078357.2XP_038934285.1  ras-related protein Rap-1b isoform X1

      UniProtKB/Swiss-Prot
      Q62636, Q6J167
      UniProtKB/TrEMBL
      A0A8L2UI57, A6IGU3
      Conserved Domains (1) summary
      cd04175
      Location:3167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    RNA

    1. XR_010052940.1 RNA Sequence

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