mt-Co2 cytochrome c oxidase II, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Co2provided by RGD
Official Full Name: cytochrome c oxidase II, mitochondrialprovided by RGD
Primary source: RGD:621872
See related: AllianceGenome:RGD:621872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: COII; COX2
Summary: Predicted to enable copper ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Involved in lactation and response to hypoxia. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Biomarker of acute myocardial infarction; colorectal carcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including MT-CO2 (mitochondrially encoded cytochrome c oxidase II). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (7006..7689)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (7006..7689)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Title: Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Cholate Disrupts Regulatory Functions of Cytochrome c Oxidase.
Title: Cholate Disrupts Regulatory Functions of Cytochrome c Oxidase.
COX-2/PGE2 facilitates fracture healing by activating the Wnt/beta-catenin signaling pathway.
Title: COX-2/PGE2 facilitates fracture healing by activating the Wnt/β-catenin signaling pathway.
Bradykinin and interleukin-1beta synergistically increase the expression of cyclooxygenase-2 through the RNA-binding protein HuR in rat dorsal root ganglion cells.
Title: Bradykinin and interleukin-1β synergistically increase the expression of cyclooxygenase-2 through the RNA-binding protein HuR in rat dorsal root ganglion cells.
Superoxide anion production and cytochrome c reduction are the consequences of the stimulated NADH consumption by cytochrome b5 reductase upon complex formation with cytochrome c and suggest a major role of this enzyme as an anti-apoptotic protein during cell death.
Title: Cytochrome b(5) reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c.
tumor necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxia at least partly via potentiation of energy generation
Title: Tumor necrosis factor receptor-associated protein 1 improves hypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II.
Specifically, our results suggest that CL 18:2omega6 content may positively influence mitochondrial COX activity thereby making this lipid molecule a potential factor related to mitochondrial health and function in skeletal muscle.
Title: Cardiolipin linoleic acid content and mitochondrial cytochrome c oxidase activity are associated in rat skeletal muscle.
Neuroprotective effects of triptolide might partially be related to its inhibitory effect on expression of COX-2 and PGE2.
Title: Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells.
VEGF production in PDGF-stimulated Hepatic stellate cells is dependent on the overexpression of COX-2 protein via the
Title: Hepatic stellate cells produce vascular endothelial growth factor via phospho-p44/42 mitogen-activated protein kinase/cyclooxygenase-2 pathway.
Berry diets did not alter COX-2 levels, but blueberry diet significantly reduced MnSOD levels in rats with reflux-induced esophageal adenocarcinoma.
Title: Effect of freeze-dried berries on the development of reflux-induced esophageal adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Cox2; co2; COII

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
contributes_to cytochrome-c oxidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome c oxidase subunit II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001665.2 Reference assembly

Range

7006..7689

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_665632.1 cytochrome c oxidase subunit II (mitochondrion) [Rattus norvegicus]

See identical proteins and their annotated locations for YP_665632.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P00406, Q37738, Q80WI7

UniProtKB/TrEMBL

A0A097PE04, Q5UAJ6, Q8SEZ5, S5RZM8

Conserved Domains (1) summary

MTH00098
Location:1 → 227

COX2; cytochrome c oxidase subunit II; Validated