L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: L3mbtl3provided by RGD
Official Full Name: L3MBTL histone methyl-lysine binding protein 3provided by RGD
Primary source: RGD:1305474
See related: EnsemblRapid:ENSRNOG00000011720 AllianceGenome:RGD:1305474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including histone binding activity; identical protein binding activity; and methylation-dependent protein binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of DNA methylation-dependent heterochromatin formation. Predicted to act upstream of or within erythrocyte maturation; granulocyte differentiation; and macrophage differentiation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 77.3), Thymus (RPKM 56.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (20807679..20908609)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (18988763..19089247)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (19998776..20097298)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within granulocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lethal(3)malignant brain tumor-like protein 3

Names: L3MBTL3, histone methyl-lysine binding protein; l(3)mbt-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432316.1 → NP_001419245.1 lethal(3)malignant brain tumor-like protein 3 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7
NM_001432318.1 → NP_001419247.1 lethal(3)malignant brain tumor-like protein 3 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7
NM_001432319.1 → NP_001419248.1 lethal(3)malignant brain tumor-like protein 3 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ADW7, A0A8I6AH98
NM_001432320.1 → NP_001419249.1 lethal(3)malignant brain tumor-like protein 3 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ADW7, A0A8I6AH98
NM_001432321.1 → NP_001419250.1 lethal(3)malignant brain tumor-like protein 3 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ADW7, A0A8I6AH98

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

20807679..20908609

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276392.1 → XP_063132462.1 lethal(3)malignant brain tumor-like protein 3 isoform X2
XM_006227696.5 → XP_006227758.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_063276409.1 → XP_063132479.1 lethal(3)malignant brain tumor-like protein 3 isoform X2
XM_006227695.5 → XP_006227757.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_039098998.2 → XP_038954926.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_039098996.2 → XP_038954924.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_039098995.2 → XP_038954923.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_063276402.1 → XP_063132472.1 lethal(3)malignant brain tumor-like protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I6ADW7, A0A8I6AH98
XM_039099000.2 → XP_038954928.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7

Related

ENSRNOP00000058121.4, ENSRNOT00000061404.6

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_039098994.2 → XP_038954922.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_003748666.6 → XP_003748714.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_003748714.1

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_039099003.2 → XP_038954931.1 lethal(3)malignant brain tumor-like protein 3 isoform X2

Related

ENSRNOP00000083485.2, ENSRNOT00000118212.2

Conserved Domains (2) summary

cd09582
Location:768 → 833

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:425 → 517

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_006227697.5 → XP_006227759.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006227759.1

UniProtKB/TrEMBL

A0A8I5ZZG3, A0A8I6ADW7

Conserved Domains (2) summary

cd09582
Location:793 → 858

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:450 → 542

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_006227699.5 → XP_006227761.1 lethal(3)malignant brain tumor-like protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ADW7, D3ZJT9

Conserved Domains (3) summary

cd09582
Location:742 → 807

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00454
Location:742 → 808

SAM; Sterile alpha motif

smart00561
Location:399 → 491

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_039099013.2 → XP_038954941.1 lethal(3)malignant brain tumor-like protein 3 isoform X4

UniProtKB/TrEMBL

A0A8I6ADW7

Conserved Domains (2) summary

cd09582
Location:717 → 782

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:374 → 466

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107612.1: Suppressed sequence

Description

NM_001107612.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from mouse, laboratory: L3mbtl3 (GeneID:237339).