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    Ythdf3 YTH N6-methyladenosine RNA binding protein F3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361920, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ythdf3provided by RGD
    Official Full Name
    YTH N6-methyladenosine RNA binding protein F3provided by RGD
    Primary source
    RGD:1305234
    See related
    EnsemblRapid:ENSRNOG00000010084 AllianceGenome:RGD:1305234
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N6-methyladenosine-containing RNA reader activity; mRNA binding activity; and ribosome binding activity. Predicted to be involved in several processes, including negative regulation of type I interferon-mediated signaling pathway; post-transcriptional regulation of gene expression; and stress granule assembly. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytoplasm. Orthologous to human YTHDF3 (YTH N6-methyladenosine RNA binding protein F3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 188.4), Kidney (RPKM 187.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ythdf3 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (100266942..100300896)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (98350304..98384608)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (100677388..100711365)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase, pseudogene 2 Neighboring gene hepatocyte nuclear factor 4, gamma Neighboring gene uncharacterized LOC134485887 Neighboring gene mitochondrial ribosomal protein L42, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity  
    enables N6-methyladenosine-containing RNA reader activity  
    enables RNA binding  
    enables mRNA binding  
    enables ribosome binding  
    Component Evidence Code Pubs
    located_in P-body  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule  

    General protein information

    Preferred Names
    YTH domain-containing family protein 3
    Names
    YTH N(6)-methyladenosine RNA binding protein 3
    YTH domain family 3
    YTH domain family protein 3
    YTH domain family, member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108546.1NP_001102016.1  YTH domain-containing family protein 3

      See identical proteins and their annotated locations for NP_001102016.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473961
      UniProtKB/TrEMBL
      A0A8I5ZZS7, A0A8I6ACC2, A6IH98
      Related
      ENSRNOP00000060081.3, ENSRNOT00000067556.3
      Conserved Domains (1) summary
      pfam04146
      Location:417550
      YTH; YT521-B-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      100266942..100300896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282042.1XP_063138112.1  YTH domain-containing family protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZS7, A0A8I6G7B6
    2. XM_063282040.1XP_063138110.1  YTH domain-containing family protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZS7
    3. XM_063282041.1XP_063138111.1  YTH domain-containing family protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZS7
    4. XM_006232168.3XP_006232230.1  YTH domain-containing family protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006232230.1

      UniProtKB/TrEMBL
      A0A8I5ZZS7, A6IH99, D3ZIY3
      Related
      ENSRNOP00000089267.2, ENSRNOT00000100939.2
      Conserved Domains (1) summary
      pfam04146
      Location:420553
      YTH; YT521-B-like domain
    5. XM_063282039.1XP_063138109.1  YTH domain-containing family protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZS7
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