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    Edn3 endothelin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Edn3provided by RGD
    Official Full Name
    endothelin 3provided by RGD
    Primary source
    RGD:2534
    See related
    EnsemblRapid:ENSRNOG00000007477 AllianceGenome:RGD:2534
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Et3; RGD1564825; preproET-3
    Summary
    Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in negative regulation of hormone secretion and regulation of neurotransmitter secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome; and Waardenburg syndrome type 4B. Orthologous to human EDN3 (endothelin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 29.8), Lung (RPKM 28.3) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Edn3 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (183980458..184004958)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (163562307..163586636)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (172856730..172879276)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 831 Neighboring gene 40S ribosomal protein S15 pseudogene Neighboring gene stathmin like, pseudogene 3 Neighboring gene uncharacterized LOC134486510 Neighboring gene uncharacterized LOC134486509

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bombesin receptor binding PubMed 
    enables endothelin B receptor binding  
    enables endothelin B receptor binding  
    enables hormone activity  
    enables hormone activity  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    NOT involved_in artery smooth muscle contraction  
    involved_in axon extension  
    involved_in axon guidance  
    acts_upstream_of cell population proliferation  
    involved_in cell surface receptor signaling pathway  
    acts_upstream_of establishment of localization in cell  
    involved_in intracellular calcium ion homeostasis  
    acts_upstream_of_or_within intracellular calcium ion homeostasis  
    acts_upstream_of_or_within intracellular magnesium ion homeostasis  
    acts_upstream_of_or_within melanocyte differentiation  
    involved_in negative regulation of hormone secretion PubMed 
    acts_upstream_of_or_within neural crest cell migration  
    acts_upstream_of_or_within neuron differentiation  
    involved_in neuron projection development  
    involved_in neutrophil chemotaxis  
    involved_in peptide hormone secretion  
    involved_in positive regulation of MAP kinase activity  
    acts_upstream_of_or_within positive regulation of cell differentiation  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of heart rate  
    involved_in positive regulation of hormone secretion  
    involved_in positive regulation of leukocyte chemotaxis  
    involved_in positive regulation of mitotic nuclear division  
    acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport  
    involved_in positive regulation of smooth muscle contraction  
    acts_upstream_of potassium ion transmembrane transport  
    acts_upstream_of_or_within regulation of cell migration  
    acts_upstream_of_or_within regulation of developmental pigmentation  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of neurotransmitter secretion PubMed 
    involved_in regulation of systemic arterial blood pressure by endothelin  
    involved_in regulation of systemic arterial blood pressure by endothelin  
    involved_in regulation of vasoconstriction  
    involved_in regulation of vasoconstriction PubMed 
    involved_in vasoconstriction  
    involved_in vasoconstriction  
    involved_in vein smooth muscle contraction  
    involved_in vein smooth muscle contraction  
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    endothelin-3
    Names
    ET-3
    PPET3
    preproendothelin-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077650.2NP_001071118.2  endothelin-3 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P13207
      UniProtKB/TrEMBL
      F1LQB0
      Related
      ENSRNOP00000009826.4, ENSRNOT00000009826.7
      Conserved Domains (2) summary
      smart00272
      Location:114135
      END; Endothelin
      pfam00322
      Location:4977
      Endothelin; Endothelin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      183980458..184004958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284294.1XP_063140364.1  endothelin-3 isoform X3

    2. XM_039105615.2XP_038961543.1  endothelin-3 isoform X4

      UniProtKB/TrEMBL
      A6KL41
      Conserved Domains (2) summary
      smart00272
      Location:158179
      END; Endothelin
      pfam00322
      Location:93121
      Endothelin; Endothelin family
    3. XM_039105613.2XP_038961541.1  endothelin-3 isoform X1

      UniProtKB/TrEMBL
      A6KL41
      Conserved Domains (2) summary
      smart00272
      Location:182203
      END; Endothelin
      pfam00322
      Location:117145
      Endothelin; Endothelin family
    4. XM_039105614.2XP_038961542.1  endothelin-3 isoform X2

      Conserved Domains (1) summary
      pfam00322
      Location:117145
      Endothelin; Endothelin family
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