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    Tmpo thymopoietin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25359, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmpoprovided by RGD
    Official Full Name
    thymopoietinprovided by RGD
    Primary source
    RGD:3875
    See related
    EnsemblRapid:ENSRNOG00000008797 AllianceGenome:RGD:3875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LAP2
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Located in nuclear inner membrane. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 428.2), Spleen (RPKM 312.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmpo in Genome Data Viewer
    Location:
    7q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (27529977..27554980, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (25642752..25667756, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (31847412..31872416, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene IKBKB interacting protein Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene uncharacterized LOC134479859 Neighboring gene transfer RNA tryptophan (anticodon CCA) 1 Neighboring gene transfer RNA aspartic acid (anticodon GUC) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables identical protein binding  
    enables lamin binding PubMed 
    enables phosphate transmembrane transporter activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in chromatin  
    located_in membrane  
    located_in nuclear envelope  
    located_in nuclear envelope  
    located_in nuclear inner membrane PubMed 
    located_in nuclear membrane  
    located_in nucleus  

    General protein information

    Preferred Names
    lamina-associated polypeptide 2, isoform beta; lamina-associated polypeptide 2
    Names
    TP beta
    Thymopoietin (lamina associated polypeptide 2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395714.1NP_001382643.1  lamina-associated polypeptide 2, isoform beta isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AFR4, A6IFV9
      Related
      ENSRNOP00000092044.1, ENSRNOT00000095834.2
      Conserved Domains (3) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam11560
      Location:459691
      LAP2alpha; Lamina-associated polypeptide 2 alpha
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    2. NM_001395715.1NP_001382644.1  lamina-associated polypeptide 2, isoform beta isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6G2M4, A6IFV6
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    3. NM_012887.2NP_037019.1  lamina-associated polypeptide 2, isoform beta isoform 2

      See identical proteins and their annotated locations for NP_037019.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q62733
      UniProtKB/TrEMBL
      A6IFV8
      Related
      ENSRNOP00000012715.4, ENSRNOT00000012715.6
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      27529977..27554980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765219.1XP_008763441.1  lamina-associated polypeptide 2 isoform X2

      See identical proteins and their annotated locations for XP_008763441.1

      UniProtKB/TrEMBL
      A0A8I5ZZ38, A6IFV7
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    2. XM_039078463.1XP_038934391.1  lamina-associated polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADD0
      Related
      ENSRNOP00000090294.1, ENSRNOT00000111659.2
      Conserved Domains (2) summary
      cd12940
      Location:110138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
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