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    Stat5a signal transducer and activator of transcription 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24918, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stat5aprovided by RGD
    Official Full Name
    signal transducer and activator of transcription 5Aprovided by RGD
    Primary source
    RGD:3773
    See related
    EnsemblRapid:ENSRNOG00000019496 AllianceGenome:RGD:3773
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Stat5
    Summary
    Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; mammary gland development; and response to ethanol. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 184.7), Muscle (RPKM 150.3) and 9 other tissues See more
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    Genomic context

    See Stat5a in Genome Data Viewer
    Location:
    10q31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86285859..86310187)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85785537..85809869)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88764732..88789060)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 3 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables double-stranded DNA binding PubMed 
    enables phosphate ion binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    Items 1 - 25 of 105
    Process Evidence Code Pubs
    acts_upstream_of B cell differentiation  
    acts_upstream_of_or_within Peyer's patch development  
    acts_upstream_of_or_within T cell differentiation in thymus  
    acts_upstream_of_or_within T cell homeostasis  
    acts_upstream_of T cell proliferation  
    acts_upstream_of activated T cell proliferation  
    acts_upstream_of cell population proliferation  
    involved_in cell surface receptor signaling pathway  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT  
    acts_upstream_of_or_within cellular response to cytokine stimulus PubMed 
    acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus  
    acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within cytokine-mediated signaling pathway  
    involved_in defense response  
    acts_upstream_of_or_within development of secondary female sexual characteristics  
    acts_upstream_of_or_within development of secondary male sexual characteristics  
    involved_in eosinophil differentiation  
    involved_in eosinophil differentiation  
    acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development  
    acts_upstream_of erythrocyte differentiation  
    acts_upstream_of_or_within female pregnancy  
    acts_upstream_of gamma-delta T cell differentiation  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in interleukin-15-mediated signaling pathway  
    involved_in interleukin-15-mediated signaling pathway  
    involved_in interleukin-2-mediated signaling pathway  
    involved_in interleukin-2-mediated signaling pathway  
    involved_in interleukin-3-mediated signaling pathway  
    involved_in interleukin-3-mediated signaling pathway  
    involved_in interleukin-4-mediated signaling pathway  
    involved_in interleukin-4-mediated signaling pathway  
    involved_in interleukin-5-mediated signaling pathway  
    involved_in interleukin-5-mediated signaling pathway  
    involved_in interleukin-7-mediated signaling pathway  
    involved_in interleukin-7-mediated signaling pathway  
    involved_in interleukin-9-mediated signaling pathway  
    involved_in interleukin-9-mediated signaling pathway  
    involved_in lactation  
    involved_in lactation PubMed 
    acts_upstream_of_or_within lactation  
    acts_upstream_of_or_within lipid storage  
    acts_upstream_of_or_within luteinization  
    acts_upstream_of lymphocyte differentiation  
    acts_upstream_of_or_within mammary gland development  
    acts_upstream_of_or_within mammary gland epithelium development  
    involved_in mammary gland involution PubMed 
    acts_upstream_of mast cell apoptotic process  
    acts_upstream_of mast cell differentiation  
    acts_upstream_of mast cell proliferation  
    acts_upstream_of mitotic cell cycle  
    acts_upstream_of myeloid cell apoptotic process  
    acts_upstream_of natural killer cell differentiation  
    acts_upstream_of_or_within natural killer cell differentiation  
    acts_upstream_of natural killer cell mediated cytotoxicity  
    involved_in negative regulation of T-helper 17 cell lineage commitment  
    involved_in negative regulation of T-helper 17 cell lineage commitment  
    acts_upstream_of_or_within negative regulation of erythrocyte differentiation  
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process  
    acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within positive regulation of B cell differentiation  
    acts_upstream_of_or_within positive regulation of T cell proliferation  
    acts_upstream_of_or_within positive regulation of activated T cell proliferation  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of blood vessel endothelial cell migration  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation  
    acts_upstream_of_or_within positive regulation of inflammatory response  
    acts_upstream_of_or_within positive regulation of interleukin-2 production  
    acts_upstream_of_or_within positive regulation of lymphocyte differentiation  
    acts_upstream_of_or_within positive regulation of mast cell differentiation  
    acts_upstream_of_or_within positive regulation of mast cell proliferation  
    acts_upstream_of_or_within positive regulation of mitotic cell cycle  
    acts_upstream_of_or_within positive regulation of multicellular organism growth  
    acts_upstream_of_or_within positive regulation of natural killer cell differentiation  
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within prostate gland epithelium morphogenesis  
    involved_in reelin-mediated signaling pathway  
    acts_upstream_of_or_within reelin-mediated signaling pathway  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of cell adhesion  
    involved_in regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of epithelial cell differentiation  
    involved_in regulation of multicellular organism growth  
    acts_upstream_of_or_within regulation of steroid metabolic process  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in response to ethanol PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to peptide hormone  
    acts_upstream_of_or_within response to peptide hormone  
    involved_in signal transduction  
    acts_upstream_of_positive_effect taurine metabolic process  
    involved_in thrombopoietin-mediated signaling pathway  
    involved_in transcription by RNA polymerase II PubMed 
    acts_upstream_of transcription by RNA polymerase II  
    Items 1 - 25 of 105
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    signal transducer and activator of transcription 5A
    Names
    mammary gland factor
    signal transducer and activator of transcription 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017064.2NP_058760.2  signal transducer and activator of transcription 5A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q62771
      UniProtKB/TrEMBL
      A6HJ62, G3V8K7
      Related
      ENSRNOP00000026662.2, ENSRNOT00000026662.5
      Conserved Domains (4) summary
      cd10421
      Location:573712
      SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:4124
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86285859..86310187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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