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    Ptpro protein tyrosine phosphatase, receptor type, O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50677, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptproprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Oprovided by RGD
    Primary source
    RGD:62068
    See related
    EnsemblRapid:ENSRNOG00000006231 AllianceGenome:RGD:62068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GLEPP1; RPTP-BK
    Summary
    Enables protein tyrosine phosphatase activity. Involved in negative regulation of glomerular filtration. Predicted to be located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 130.6), Brain (RPKM 85.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ptpro in Genome Data Viewer
    Location:
    4q43-q44
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171895104..172105911)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (170164071..170374790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (171250766..171461571)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAS-like, estrogen-regulated, growth-inhibitor Neighboring gene uncharacterized LOC134486652 Neighboring gene uncharacterized LOC134486857 Neighboring gene prohibitin 1, pseudogene 5 Neighboring gene uncharacterized LOC120102421 Neighboring gene EGFR pathway substrate 8, signaling adaptor Neighboring gene uncharacterized LOC134486858 Neighboring gene serine/threonine kinase receptor associated protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    enables cadherin binding  
    enables cadherin binding  
    enables histone H2AXY142 phosphatase activity  
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity PubMed 
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity, metal-dependent  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in axon guidance  
    involved_in axon guidance  
    involved_in cell morphogenesis  
    involved_in cell morphogenesis  
    involved_in chromatin remodeling  
    involved_in glomerulus development  
    involved_in glomerulus development  
    involved_in lamellipodium assembly  
    involved_in lamellipodium assembly  
    involved_in monocyte chemotaxis  
    involved_in monocyte chemotaxis  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of glomerular filtration PubMed 
    involved_in nervous system development PubMed 
    involved_in peptidyl-tyrosine dephosphorylation  
    involved_in peptidyl-tyrosine dephosphorylation  
    involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity  
    involved_in podocyte differentiation  
    involved_in podocyte differentiation  
    involved_in podocyte differentiation  
    involved_in regulation of glomerular filtration  
    involved_in regulation of glomerular filtration  
    involved_in regulation of glomerular filtration  
    involved_in regulation of synapse organization  
    involved_in slit diaphragm assembly  
    involved_in slit diaphragm assembly  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    is_active_in GABA-ergic synapse  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in dendritic spine  
    located_in dendritic spine  
    is_active_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density membrane  

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase O
    Names
    Glomerular epithelial protein 1
    receptor-type protein tyrosine phosphatase D30
    NP_059032.1
    XP_006237633.1
    XP_017448340.1
    XP_038964206.1
    XP_038964207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017336.2NP_059032.1  receptor-type tyrosine-protein phosphatase O precursor

      See identical proteins and their annotated locations for NP_059032.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AS38, F7F9Z5, Q62797
      Related
      ENSRNOP00000044055.3, ENSRNOT00000040576.5
      Conserved Domains (4) summary
      smart00194
      Location:9371192
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:9651193
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:434526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:725805
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      171895104..172105911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592851.3XP_017448340.1  receptor-type tyrosine-protein phosphatase O isoform X1

      UniProtKB/TrEMBL
      A0A8I5YC57, F7F9Z5
      Related
      ENSRNOP00000077071.1, ENSRNOT00000097203.2
    2. XM_039108278.2XP_038964206.1  receptor-type tyrosine-protein phosphatase O isoform X2

      Conserved Domains (2) summary
      cd00063
      Location:434526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:725805
      fn3; Fibronectin type III domain
    3. XM_039108279.2XP_038964207.1  receptor-type tyrosine-protein phosphatase O isoform X3

      UniProtKB/TrEMBL
      A6IMK3
      Conserved Domains (2) summary
      cd00063
      Location:434526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:725805
      fn3; Fibronectin type III domain
    4. XM_006237571.5XP_006237633.1  receptor-type tyrosine-protein phosphatase O isoform X4

      Conserved Domains (2) summary
      smart00194
      Location:126381
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:154382
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
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